Anhydrous Dialysis Precursor Composition Moisture Barrier
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Solution Overview
Problem
Current dialysis precursor compositions face issues with chemical degradation, caking, lump formation, and discoloration due to humidity, leading to stability and shelf-life problems, as well as challenges in ensuring proper composition and concentration of components in ready-for-use dialysis solutions.
Innovation Solution
A dialysis acid precursor composition comprising anhydrous glucose and anhydrous magnesium salts, sealed in a moisture-resistant container with a water vapor transmission rate less than 0.3 g/m2/d at 38° C./90% RH, which prevents moisture ingress and maintains stability, and includes a method for mixing with water and other concentrates to produce a ready-for-use dialysis solution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If dialysis precursor composition is stored in conventional containers, then ease of storage is improved, but chemical degradation and caking occur due to humidity ingress
Solution Approach 1:
The patent employs a flexible foil container made of aluminum and plastic layers that provides moisture barrier protection while maintaining ease of storage. The foil container prevents humidity ingress that causes caking and chemical degradation, yet remains practical for storage and handling in dialysis settings.
Solution Approach 2:
The container creates a protected internal environment that isolates the precursor composition from ambient humidity. This inert barrier atmosphere prevents moisture-related degradation reactions while maintaining the stability and solubility of the composition components during storage.
2Reliability
If moisture-resistant packaging is used, then stability is improved, but device complexity increases
Solution Approach 1:
The foil container uses thin film technology to achieve effective moisture protection without requiring complex multi-component packaging systems. The flexible foil structure provides adequate barrier properties through its material composition and sealing design, avoiding unnecessary complexity.
3Duration of action of stationary object
If anhydrous components are used, then shelf life is improved, but solubility challenges arise
Solution Approach 1:
The container is pre-filled with anhydrous precursor composition in a controlled manufacturing environment. The preliminary sealing and protection from moisture ingress ensure that the anhydrous components maintain their stability and solubility characteristics until the moment of use, when water is added to the container.
Solution Approach 2:
The container design enables the user to simply add water to the anhydrous precursors, and the container itself facilitates the mixing process. The precursors are formulated to dissolve properly when water is added, with the container providing the necessary environment for complete dissolution without requiring additional intervention.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides improved stability, reduced chemical degradation, extended shelf life, cost savings, and environmental benefits by maintaining the stability and solubility of components, ensuring a consistent and effective dialysis solution.
Implementation Method 1
sealed in a moisture-resistant container with a water vapor transmission rate less than 0.3 g/m2/d at 38° C./90% RH
Data Source
AI summary
The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. The dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one magnesium salt, and optionally potassium salt, and calcium salt. According to the invention the glucose and the at least one magnesium salt, are present as anhydrous components in the dialysis acid precursor composition.