Anionic Cannabinoid Molecules for Water-Soluble Beverages

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Solution Overview

Problem

Cannabinoids lacking a carboxyl group are insoluble in water, leading to unstable emulsions with undesirable flavor and poor bioavailability, posing challenges for beverage production and consumer confidence.

Innovation Solution

The development of anionic cannabinoid molecules, specifically 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate, which are water-soluble at mildly-alkaline pH, allowing for stable and bioavailable formulations with rapid absorption and distinct color changes for authentication.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If cannabinoids are suspended in water to produce beverages, then water-based beverage production is enabled, but the emulsions display undesirable flavor and poor bioavailability

Engineering Contradiction:

Improvebeverage production capabilityVSAvoidbioavailability

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent changes the chemical parameter of cannabinoids by converting them to anionic forms through reaction with base metals or metal oxides. This parameter change transforms the molecular properties, enabling water solubility while maintaining or improving bioavailability, thus resolving the contradiction between beverage production capability and bioavailability

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite structures by forming coordination complexes between cannabinoid molecules and metal ions (such as aluminum, calcium, or zinc). These composite anionic cannabinoid molecules combine the pharmacological properties of cannabinoids with the water-soluble characteristics of metal complexes, enabling both beverage production and high bioavailability

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If cannabinoids are suspended in water through emulsification, then water-based formulations are achieved, but the emulsions display undesirable flavor

Engineering Contradiction:

Improvewater-based formulationVSAvoidundesirable flavor

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical parameter of cannabinoids from neutral to anionic form, which fundamentally alters their interaction with water and taste receptors. This parameter change eliminates the need for emulsification and produces naturally water-soluble formulations with acceptable flavor profiles

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces metal ions (Al³⁺, Ca²⁺, Zn²⁺, etc.) as intermediaries that mediate between the hydrophobic cannabinoid molecules and water. These metal ions form soluble complexes that act as bridges, enabling water solubility without requiring emulsifiers that contribute to undesirable flavor

Inventive Principle:

Principle #24Intermediary (Mediator)

3Quantity of substance

If cannabinoids are made water-soluble through conventional methods, then solubility is improved, but stability and bioavailability deteriorate

Engineering Contradiction:

Improvewater solubilityVSAvoidstability

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent creates stable composite materials by forming coordination complexes between cannabinoid molecules and metal ions. These composite anionic cannabinoid structures maintain molecular integrity in water, providing both solubility and stability simultaneously through the robust metal-ligand coordination bonds

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent applies local quality modification by selectively modifying specific regions of the cannabinoid molecule through coordination with metal ions at functional groups such as carboxyl or hydroxyl groups. This localized modification enables water solubility without disrupting the overall molecular structure and pharmacological activity, maintaining stability

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The anionic cannabinoid molecules provide beverages with enhanced bioavailability, rapid onset of pharmacological effects, and consumer confidence through visible color changes, overcoming previous solubility and stability issues.

Implementation Method 1

anionic cannabinoid molecules are water-soluble at mildly-alkaline pH

Methodology Applied

Scientific EffectIon-dipole interaction:

Implementation Method 2

rapid absorption and distinct color changes for authentication

Methodology Applied

Scientific EffectPassive diffusion: Diffusion

Data Source

PatentUS10555914B1Methods of producing anionic cannabinoid molecules dissolved in water

Publication Date: 2020.02.11 NATURAL EXTRACTION SYSTEMS LLC

AI summary

Various aspects of this patent document relate to methods to produce compositions comprising anionic cannabinoid molecules.