Aronia Extract Composition for Gut Dysbiosis and Arterial Stiffness
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Solution Overview
Problem
Current treatments for cardiovascular disease (CVD) and gut dysbiosis are inadequate, particularly in individuals with reduced gut gene count, and the mechanisms behind arterial stiffness and hypertension are not fully understood.
Innovation Solution
Aronia melanocarpa extracts are used to treat and prevent CVD and gut dysbiosis by reducing arterial stiffness, hypertension, and increasing gut microbiome diversity through the administration of Aronia melanocarpa extracts, which enhance the levels of beneficial bacteria such as Faecalibacterium prausnitzii, Lawsonibacter asaccharolyticus, and Intestinimonas butyriciproducens.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for CVD and gut dysbiosis, then existing therapeutic effects are achieved, but the treatments are inadequate particularly in individuals with reduced gut gene count
Solution Approach 1:
The patent identifies specific parameter changes in gut microbiome composition (increasing diversity, increasing beneficial bacteria like Faecalibacterium prausnitzii, Lawsonibacter asaccharolyticus, and Intestinimonas butyriciproducens) as the mechanism by which Aronia melanocarpa extract resolves the contradiction between conventional treatment effectiveness and adaptability to individuals with reduced gut gene count
Solution Approach 2:
The patent introduces Aronia melanocarpa extract as an intermediary substance that mediates between the reduced gut gene count condition and the desired therapeutic outcomes for both CVD and gut dysbiosis, achieving effects that conventional treatments cannot accomplish in this specific population
2Reliability
If Aronia melanocarpa extracts are administered to increase gut microbiome diversity, then beneficial effects on cardiovascular health are achieved, but the mechanisms behind arterial stiffness and hypertension are not fully understood
Solution Approach 1:
The patent establishes feedback loops where the administration of Aronia melanocarpa extract leads to increased gut microbiome diversity, which in turn produces beneficial metabolites that improve cardiovascular health markers including reduced arterial stiffness and hypertension, creating a measurable feedback mechanism
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Aronia melanocarpa extracts effectively reduce arterial stiffness and hypertension while increasing gut microbiome diversity, providing a beneficial effect on cardiovascular health and gut health by modulating the gut microbiota.
Implementation Method 1
increasing gut microbiome diversity through the administration of Aronia melanocarpa extracts, which enhance the levels of beneficial bacteria such as Faecalibacterium prausnitzii, Lawsonibacter asaccharolyticus, and Intestinimonas butyriciproducens
Implementation Method 2
Aronia melanocarpa extracts effectively reduce arterial stiffness and hypertension while increasing gut microbiome diversity
Data Source
AI summary
The present invention relates to compositions for use in treating cardiovascular disease (CVD) and/or gut dysbiosis, and methods of treating CVD and/or gut dysbiosis. In particular, the present invention relates to compositions for use and methods for treating cardiovascular disease (CVD) and/or gut dysbiosis in subject groups having a reduced gut gene count (faecal microbiome gene count).