Microbiological Testing/Measurement TRIZ Cases

qPCR-based miRNA profiling and a predictive score distinguish pre-, receptive, and post-receptive endometrial states.

Cultivar 22080706 uses CRISPR and transformation to accelerate stable development of herbicide-resistant soybeans.

A covalent polymerase-nucleotide conjugate uses dwell-time detection to support accurate, lower-cost high-throughput sequencing.

This workflow combines NGS amplification and Sanger sequencing to validate results without separate validation experiments.

Planned crossing and genetic methods help cultivar 21120238 combine yield, disease resistance, and altered fatty acid profiles.

This soybean case uses preselected parental lines and structured breeding to combine yield, disease resistance, and fatty acid traits.

A unified workflow tags DNA and RNA with UMIs and TSOs, then produces separate libraries for flexible sequencing.

This case combines a two-lane drawer, magnetic sample extraction, and simultaneous cutting and heated sealing to reduce technician handling.

A binding-moiety polymerase conjugate stabilizes sequencing complexes for longer reads.

A transverse engraved line marks cutting deviations, protecting electrodes while reducing laser travel and simplifying quality inspection.

This case uses eDNA and eRNA measurements with a prediction model to subtract foreign nucleic acids from freshwater fish surveys.

This 3C process uses controlled nuclease digestion and linker ligation to map regulatory interactions at single-base resolution.

This extraction approach uses heating to aggregate an antibody-copolymer conjugate, simplifying PCR sample purification and concentration.

Segmented DNA-RNA-DNA probes use RNase H2 cleavage to distinguish STR alleles without bulky capillary electrophoresis.

This case targets twelve COASY promoter CpG sites in blood DNA to indicate Alzheimer’s risk without spinal fluid testing.

Reversible terminator imaging enables compact, high-throughput sequencing with lower reagent use.

Light photocleavage breaks clogged biopolymers, while motive forces flush fragments to restore nanofluidic and microfluidic throughput.

Measure MTAP expression before treatment to predict STING agonist susceptibility and guide cancer patient selection.

Capture probes map analyte distribution across tissue locations, helping plan complete resection and reduce re-excision risk.

Antibody reactions enable rapid, selective detection of multiple Enterobacteriaceae genera.

This case selects variant-free amplicons with balanced homopolymer lengths to improve sequencing recalibration and accuracy.

This assay uses stable labeled probes to detect native nucleic acids without washing, qPCR, cDNA generation, antibodies, or radioactivity.

Two probes bind opposite exon segments, link into one molecule, and enable accurate splice-junction localization.

Raman-based TAIC profiling uses reference comparisons and machine learning to assess cancer type, stage, and metastasis.

This case uses MYC and JUN copy numbers to identify resistant tumors and pair RASMULTI inhibitors with TEAD blockade.

Measure connexin 37 and 43 expression ratios in blood to support sensitive, specific, and simple dementia detection.

Cyclodextrin-polymer hydrogels stabilize droplets at PCR temperatures while preserving merging and injection in microfluidic workflows.

Barcoded templated ligation probes preserve spatial context while improving targeted RNA detection and reducing reagent costs.

This case uses Aronia melanocarpa extract to increase beneficial bacteria and address arterial stiffness and hypertension.

This case uses biomarker screening and IL-17A/F nanobodies to target resistant pathway variants and enable earlier treatment.

In situ reporter probes move to a clean planar support, preserving spatial relationships for multiplexed, high-resolution detection.

This case uses FET-based active electrodes and bead-loaded microwells to combine sensitive detection with CMOS VLSI integration.

Unique oligonucleotide tags let capture agents remain bound while iterative probe cycles reveal more than 40 epitopes.

Ribosome-targeted probes profile translated RNA in single cells with spatial precision.

Reset specimen routes after abnormalities to reduce analysis delays.

Full-length RNA processing removes housekeeping transcripts, reducing data redundancy for biomarker discovery and RNA vaccine development.

Blood sequencing can lose transcript detail; full-length RNA processing preserves isoforms for diagnosis, monitoring, and RNA vaccines.

Chimeric D/L-nucleic acid probes separate target hybridization from immobilization, improving capture purity for downstream assays.

Linear oligo hybridization chain reaction improves signal specificity and imaging speed across larger autofluorescent tissue areas.

A pipette mechanism and automated scheduling coordinate reagent transfer across multiple biochips, improving flux and reagent utilization.

Reversible thermogel polymers switch gel and liquid states to limit reagent waste while supporting accurate, efficient sequencing.

This case models probe-related coverage bias from healthy samples, enabling base-level normalization and more accurate CNV calls.

Competitive enzyme kinetics and supervised learning identify and quantify known or unknown anticoagulant inhibitors in one blood test.

Partitioned organelles are lysed, converted to barcoded cDNA, pooled, and sequenced while preserving sample origin.

This case uses ctFE thresholds and mutation filtering to calculate bTMB accurately from targeted liquid biopsy sequencing.

Phi6-encapsulated RNA controls resist heat and ribonuclease degradation without cold storage.

Marker-linked Eh1 and Eh2 genes support rapid breeding of powdery mildew-resistant carrots while reducing fungicide reliance.

Position-specific glycosyltransferases target C-3 and other hydroxyl sites, improving rare ginsenoside yield while reducing material loss.

Analyze cfDNA fragment endpoints to identify tissue origin when genomes are alike.

The case uses pathway probes and protein markers to detect T-cell IL-6 signaling and predict relapse in remission patients.