Azido-amine Derivative Extraction Solvent Selection

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Solution Overview

Problem

Existing methods for producing azido-amine derivatives face issues such as time-lapse degradation, safety concerns due to abnormal heat generation during condensation, and the use of carcinogenic solvents like methylene chloride, which are not suitable for industrial-scale production.

Innovation Solution

The method involves using aromatic solvents like toluene or ether solvents like diisopropyl ether or tert-butyl methyl ether for post-treatment and condensation of azido-amine derivatives, which inhibits degradation and raises the heat generation initiation temperature, ensuring safer and more efficient industrial-scale production.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If methylene chloride is used as solvent for liquid separation extraction, then the extraction process can be completed, but the objective compound undergoes time-lapse degradation and abnormal heat generation occurs during condensation

Engineering Contradiction:

Improveextraction processVSAvoidcompound stability

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent changes the solvent parameter from methylene chloride to aromatic solvents (toluene, xylene) or ether solvents (diisopropyl ether, tert-butyl methyl ether). This parameter change resolves the contradiction by maintaining extraction effectiveness while eliminating compound degradation and abnormal heat generation during condensation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent replaces the problematic methylene chloride solvent with alternative solvents that can be easily disposed of after use. The new solvents (aromatic or ether types) do not cause compound degradation or safety issues, allowing for safe disposal after completing the extraction function.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Ease of manufacture

If methylene chloride is used as solvent, then liquid separation extraction can be performed, but abnormal heat generation occurs with low initiation temperature (about 82°C) causing safety problems

Engineering Contradiction:

Improveextraction processVSAvoidheat generation safety

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent changes the solvent parameter from methylene chloride to aromatic solvents (toluene, xylene) or ether solvents (diisopropyl ether, tert-butyl methyl ether). This parameter change raises the heat generation initiation temperature from 82°C to higher temperatures, eliminating the safety hazard while maintaining extraction effectiveness.

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If methylene chloride is used as solvent, then extraction can be completed, but the solvent is carcinogenic and not preferred for human body

Engineering Contradiction:

Improveextraction processVSAvoidcarcinogenicity

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the carcinogenic methylene chloride with alternative aromatic or ether solvents that are less harmful to human health. These substitute solvents can be used for extraction and then disposed of, eliminating the carcinogenicity issue while maintaining the extraction function.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent introduces aromatic solvents (toluene, xylene) or ether solvents (diisopropyl ether, tert-butyl methyl ether) as intermediary substances to perform the extraction function. These intermediary solvents replace the harmful methylene chloride, achieving the same extraction purpose without carcinogenic effects.

Inventive Principle:

Principle #24Intermediary (Mediator)

4Productivity

If conventional methods are used for industrial scale production, then production can proceed, but time-lapse degradation and safety issues prevent efficient mass production

Engineering Contradiction:

Improveindustrial scale productionVSAvoidcompound stability and safety

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent changes the solvent parameter from methylene chloride to aromatic or ether solvents, which resolves both the compound stability issue (preventing time-lapse degradation) and safety issues (raising heat generation initiation temperature). This enables reliable industrial-scale production while maintaining productivity.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively prevents time-lapse degradation and enhances safety by shifting the heat generation initiation temperature to higher values, enabling the production of azido-amine derivatives on an industrial scale without the hazards associated with traditional solvents.

Implementation Method 1

a step of extracting the azido-amine derivative represented by formula (II), obtained by using an aromatic solvent or an ether solvent

Methodology Applied

Scientific EffectLiquid-liquid extraction: Liquid-Liquid Extraction

Data Source

PatentUS9896408B2Method for producing azido-amine derivative

Publication Date: 2018.02.20 FUJIFILM WAKO PURE CHEMICAL CORP

AI summary

A method for producing an azido-amine derivative includes obtaining an azido-amine derivative and extracting the azido-amine derivative obtained by using an aromatic solvent or an ether solvent.