Commensal Bacteroides OMVs for Mucosal Biologic Delivery
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Solution Overview
Problem
Existing technologies have not effectively utilized the non-pathogenic role of commensal bacteria-derived outer membrane vesicles (OMVs) for delivering biologics to the gastrointestinal and respiratory tracts to prevent infection, tumor growth, and tissue inflammation.
Innovation Solution
Development of pharmaceutical preparations using native OMVs from Gram-negative commensal bacteria like Bacteroides, which include biologically active peptides and proteins, delivered via a pharmaceutically acceptable carrier such as PBS, to prime and boost immune responses and act as adjuvants for vaccines.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If OMVs are used to deliver biologics to the gastrointestinal and respiratory tracts, then immune response is enhanced and protection against infection and inflammation is provided, but the technology has not been effectively utilized until now
Solution Approach 1:
The patent uses OMVs as intermediary carriers to deliver biologics (proteins, peptides, antibodies) to the gastrointestinal and respiratory tracts. The OMVs act as a mediator that protects the biologics from degradation and facilitates their delivery to target sites, resolving the issue of ineffective biologic delivery through these mucosal routes.
Solution Approach 2:
The patent modifies the parameters of OMVs by incorporating specific biologics into them, changing their functional properties. This allows the OMVs to be tailored for specific therapeutic applications, enhancing their versatility and effectiveness for delivering different types of biologics to prevent infection, tumor growth, and inflammation.
2Quantity of substance
If conventional vaccine delivery methods are used, then vaccine doses required are high, but immune response priming and boosting efficiency is low
Solution Approach 1:
The OMVs are derived from commensal bacteria that naturally interact with the host immune system. This self-service mechanism allows the OMV-delivered biologics to efficiently prime and boost immune responses without requiring high doses, as the OMVs themselves are recognized by the immune system and facilitate antigen presentation and immune cell activation.
Data Source
AI summary
Pharmaceutical compositions and preparation including outer membrane vesicles (OMVs) and at least one pharmaceutically acceptable carrier wherein said OMVs are native OMVs produced by the Gram-negative commensal bacteria Bacteroides.