BAF Complex Modulating Antivirals for Coronavirus

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Solution Overview

Problem

There is a need for effective antiviral agents to treat or prevent SARS-CoV-2 infection, as current therapies are limited and not all recommended by medical guidelines.

Innovation Solution

BAF complex modulating compounds, specifically those that inhibit ARID1A-containing BAF complexes, are used as antiviral agents to treat or prevent coronavirus infections.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional antiviral therapies are used, then treatment options are limited, but the effectiveness and safety profile are insufficient

Engineering Contradiction:

Improvetreatment optionsVSAvoideffectiveness and safety

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent changes the molecular target parameter from conventional viral proteins to the host BAF complex, specifically inhibiting ARID1A-containing BAF complexes. This parameter change enables new treatment options with improved effectiveness and safety by targeting a previously unexplored host factor mechanism

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent introduces host factors (BAF complex) as intermediaries between the virus and cellular machinery. By inhibiting the BAF complex, the compound disrupts the viral life cycle indirectly through host protein inhibition, providing a novel therapeutic approach that avoids direct viral targeting

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If BAF complex modulating compounds are used, then antiviral effectiveness is improved, but the mechanism of action is novel and requires validation

Engineering Contradiction:

Improveantiviral effectivenessVSAvoidmechanism validation

Core Design Contradiction:

ReliabilityVSDifficulty of detecting and measuring

Solution Approach 1:

The patent employs feedback mechanisms through CRISPR screen data and viral replication assays to validate the mechanism of action. The inhibition of BAF complex leads to measurable changes in viral replication kinetics, providing feedback that confirms the antiviral effectiveness and validates the molecular mechanism

Inventive Principle:

Principle #23Feedback

3Adaptability or versatility

If existing antivirals are used, then treatment guidelines are followed, but the compounds lack broad spectrum activity and specific mechanism insights

Engineering Contradiction:

Improvebroad spectrum activityVSAvoidmechanism insights

Core Design Contradiction:

Adaptability or versatilityVSLoss of information

Solution Approach 1:

The patent demonstrates universality by showing that BAF complex inhibition affects multiple aspects of viral replication and host cell functions. The compound exhibits broad-spectrum activity against coronaviruses while providing mechanistic insights into host-factor dependency, combining therapeutic breadth with scientific understanding

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS12202808B2Substituted antivirals for treating coronavirus infection

Publication Date: 2025.01.21 PURDUE RES FOUND

AI summary

The invention provides a BAF complex modulating compound for use as a coronavirus antiviral; wherein the BAF complex modulating compound is of Formula (I):