Organic Active Ingredients TRIZ Cases

Low-activity, poorly druggable ferroptosis inhibitors motivate phenothiazine compounds with stronger inhibition and good cardiac safety.

Novel Formula I compounds target wild-type c-KIT kinase while limiting off-target signaling and CNS side effects in mast cell disorders.

Benzimidazole dimers act as STING agonists or antagonists, regulating type I interferon production for immune activation or suppression.

Multiple anhydrous, hydrated, and salt forms support stable pralsetinib compositions for consistent oral dosage development.

Disulfide linkers respond to tumor-cell glutathione, keeping SN-38 stable in normal cells and releasing it selectively.

Current KRAS G12C cancer treatments lack effective inhibitors; heteroaryl compounds are varied to selectively inhibit the mutant protein.

Crystalline diaminopyrimidine forms address poor solubility, dissolution, stability, and bioavailability through defined XRPD and DSC/TGA profiles.

Hot-melt extrusion combines telmisartan, meglumine, and polymer to form an amorphous dispersion for faster dissolution.

HDAC inhibitor payloads use antibody-linked structures to improve solid-tumor delivery while increasing plasma stability and cellular internalization.

Unchecked coronavirus replication is addressed with 5-amino phthalazinedione, which reduces viral load for treatment or prophylaxis.

Short-lived ERT clears Gb3 but leaves fibrosis progression; combining agalsidase-β with TGF-β inhibitors targets both limits.

Existing DYRK2 inhibitors show weak activity; benzothiazole pyrimidineamine structures tune potency and kinase selectivity.

Polysorbate and polyoxyl 40 stearate form nanomicelles that improve enavogliflozin eye-drop stability and intraocular exposure.

This case links (5R)-5-hydroxytriptolide with NF-κB and CD4+ T-cell inhibition to control AIDS immune activation with low cytotoxicity.

A formulation combining prebiotic oligosaccharides with beta-casein boosts beneficial bacteria and suppresses pathogens in infant gut microbiota.

Replacing silica carriers with sugar-based excipients helps tablets retain unstable active ingredients while preserving permeability and rapid disintegration.

Extensive deoxygenation adds equipment and time; heated dissolution, nitrogen cooling, and cysteine stabilization support paracetamol shelf-life.

New pyrrole compounds target fungal infections while changing molecular structure to address resistance and human CYP inhibition.

FFF printing builds the capsule shell while a separate dispenser fills the core, supporting customized dosage forms and improved drug stability.

A single pullwire bends one applicator to multiple sinus, nasal, ear, and throat targets while the fixed handle improves ergonomics.

Controlled crystallization of Asciminib mesylate targets solid-form stability and processing needs while supporting bioavailability optimization.

Cold atmospheric plasma transfers RONS into a hydrogel for localized cancer-cell killing while supporting bone tissue regeneration.

Arnica helenalin and flavonoids provide anti-inflammatory and antioxidant activity, while sodium hyaluronate supports lubrication for dry eye.

Intramolecular tricyclic benzotriazole derivatives inhibit Keap1 and activate Nrf2, offering potential antioxidant and therapeutic benefits for renal disease.

Changing substituents on a fused-piperidine scaffold targets rapid 5-HT2A-mediated antidepressant effects while avoiding hallucinogenic side effects.

IVL peptides and vitamin D receptor agonists improve skin barrier integrity and support atopic dermatitis treatment.

Linker composition and AR-binding substituents are varied to maintain receptor degradation while improving solubility and metabolic stability.

Variable absorption can make corneal neovascularization treatment inconsistent; naphthylurea eye drops provide targeted ocular delivery.

Selective 5-HT2A modulation with reduced 5-HT2B agonism supports non-hallucinogenic, non-cardiotoxic options for at-home psychological disorder treatment.

See how AMBMP analogs activate CaMKII and metabolic pathways to increase muscle mass, function, and oxidative capacity in muscular dystrophy.

Non-canonical TERT inhibition sensitizes cancer cells to genotoxic therapy while reducing treatment resistance and enhancing immune responses.

Novel spiro aromatic compounds target SHP2’s non-catalytic region to sustain its self-inhibiting state with strong activity at low concentrations.

ABP compounds with IL-2 and IL-15 or IL-18 sustain γδ T-cell growth, improving purity and yield from smaller blood samples.

Fusogenic nanoparticles address low cell penetration by encapsulating active agents for protection from biological degradation.

See how porous resorbable pouches secure implants through tissue ingrowth while degrading naturally without surgical removal.

Low cell permeability and nuclease degradation limit siRNA delivery; an ionic liquid supports skin penetration and stability for topical IL-23 inhibition.

Chelating agents bind transition metals while stabilizers limit degradants, helping preserve epinephrine effectiveness during storage.

Inhaled dry powder esketamine bypasses first-pass metabolism to reach therapeutic plasma levels while limiting systemic metabolites and adverse effects.

Bridging cereblon and target proteins enables ubiquitination and proteasomal degradation while addressing difficult protein-protein interaction surfaces.

Relacorilant lowers an elevated neutrophil-to-lymphocyte ratio alongside cancer treatment, supporting stronger treatment response and prognosis.

Alternating fields prime M0 or M2 macrophages toward M1 before antibiotics, strengthening immune response and potentially lowering drug doses and infection duration.

Fluid-bed granulation converts brittle ipatasertib into flowable granules, reducing lamination during high-speed tableting.

Selective HDAC6 inhibition uses 1,3,4-oxadiazole homophthalimide compounds to limit class I HDAC-related fatigue and nausea.

Structural optimization tunes lipophilicity, molecular weight, and functional groups to improve RORγ modulator potency.

A non-aqueous glycerin vehicle supports oral amlodipine delivery while maintaining formulation stability and dose uniformity.

Separate Panax, rutin, and Ginkgo formulations lack synergy; a solid lipid sol-gel carrier co-delivers them for improved bioavailability.

Acidifying the polymeric film to pH 1.5–5.0 helps stabilize tryptamines, extend shelf life, and support mucosal absorption.

Defined substituents and stereochemistry help balance FASN inhibition with specificity for cancer, metabolic, and autoimmune conditions.

After ocular surgery, chondroitin sulfate eye drops cushion the ocular surface and relieve pain or discomfort during recovery.

Applying a small-molecule analgesic over paraspinal skin routes it toward the DRG, targeting pain transmission without systemic exposure.