Prefilled Glass Syringe Tip with 1.7 mm Channel for Needleless Connector

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Solution Overview

Problem

Existing needleless connectors for intravenous administration suffer from clogging and breakage issues, particularly in emergency settings, leading to unreliable delivery of medications like succinylcholine, amiodarone, and adenosine, which can result in catastrophic failures and increased risk of bloodstream infections.

Innovation Solution

A prefilled glass syringe with a Luer-lock and a syringe tip having an internal channel diameter of about 1.7 mm, designed for reversible attachment to a needleless connector with a reversed internal blunt cannula, reducing the risk of breakage and maintaining a fluid-tight seal even at elevated pressures, allowing for rapid and safe administration of emergency medications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If a needleless connector with a reversed internal blunt cannula is used, then needlestick injuries are eliminated and operation is simplified, but catheter-related bloodstream infections increase and connector complexity increases

Engineering Contradiction:

Improveoperation simplicityVSAvoidconnector complexity

Core Design Contradiction:

Ease of operationVSDevice complexity

Solution Approach 1:

The patent extracts the problematic internal blunt cannula from the needleless connector system by using a syringe tip with a large internal diameter that allows direct connection without the cannula, thereby eliminating the source of infections and mechanical failures while maintaining needleless operation simplicity

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent segments the connection system into a syringe tip with large internal diameter and a needleless connector without internal blunt cannula, separating the functions to eliminate the problematic component while maintaining the beneficial aspects of needleless operation

Inventive Principle:

Principle #1Segmentation

2Reliability

If a complex needleless connector with internal moving components is used, then reflux is minimized, but manufacturing complexity increases and connection reliability decreases

Engineering Contradiction:

Improveconnection reliabilityVSAvoidconnector complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent removes the internal moving components and blunt cannula from the needleless connector, replacing them with a simple connection interface that uses a syringe tip with large internal diameter, thereby eliminating mechanical failure points while maintaining connection reliability

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

Instead of using a narrow-bore connector with internal components to prevent reflux, the patent inverts the approach by using a large internal diameter syringe tip that allows smooth fluid flow and eliminates the need for internal flow-control mechanisms

Inventive Principle:

Principle #13The other way round (Inversion)

3Reliability

If a standard syringe tip internal diameter is used, then manufacturing is simpler, but clogging and breakage occur during insertion

Engineering Contradiction:

Improvedelivery reliabilityVSAvoidsyringe manufacturing

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent changes the critical parameter of syringe tip internal diameter from standard dimensions to a specifically enlarged dimension, which prevents clogging and breakage during insertion while maintaining manufacturing feasibility through standard glass blowing techniques

Inventive Principle:

Principle #35Parameter changes

4Productivity

If needleless pre-filled glass syringes are used in emergency situations, then rapid administration is enabled, but catastrophic failure occurs due to clogging and breakage

Engineering Contradiction:

Improveadministration speedVSAvoiddelivery reliability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent modifies the syringe tip internal diameter parameter to be significantly larger than standard, which eliminates clogging and breakage during insertion while maintaining the rapid administration capability essential for emergency situations

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent designs the syringe tip with a large internal diameter beforehand to cushion against the risks of clogging and breakage that could occur during emergency insertion, ensuring reliable drug delivery even under time-critical conditions

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Data Source

PatentUS11779535B2Succinylcholine prefilled syringe, compositions and methods

Publication Date: 2023.10.10 NEVAKAR INJECTABLES INC

AI summary

Pre-filled syringes, pharmaceutical compositions, and kits and methods relating to same allow for emergency administration of one or more drugs from prefilled glass syringes to a patient via a needleless connector. In preferred embodiments, the prefilled glass syringe has a drug volume of at least 5 mL, has a Luer-lock, and has a syringe tip with an internal channel that has a diameter of about 1.7 mm. Such syringes advantageously allow storage of emergency drugs without leaching of plastic materials and degradation, and substantially improve the safety profile where the syringe is attached to an IV line via a needleless connector.