Biphasic Ceramic Antibiotic Carrier for Deep Bone Infection Treatment

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Solution Overview

Problem

Current treatments for deep bone infections face challenges in achieving sustained local concentrations of antibiotics, leading to issues with bacterial resistance and biofilm formation, and existing carriers like PMMA lack sustained release properties and bone regeneration capabilities.

Innovation Solution

A local extended release composition using a biphasic ceramic material, such as hydroxyapatite combined with calcium sulphate, which is finely divided into micro or nanoparticles to provide a high effective surface area, and is used in conjunction with antibiotics like gentamicin, vancomycin, and rifampicin to treat bacterial infections.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If polymethylmethacrylate (PMMA) containing antibiotics is used for local delivery, then high local antibiotics levels can be achieved, but sustained release is not provided and bone regeneration properties are lacking

Engineering Contradiction:

Improvelocal antibiotics levelsVSAvoidsustained release

Core Design Contradiction:

Quantity of substanceVSDuration of action of moving object

Solution Approach 1:

The patent uses a composite material consisting of PMMA beads combined with hydroxyapatite particles. The PMMA provides sustained release of antibiotics through controlled degradation, while the hydroxyapatite particles provide bone regeneration properties. This composite structure resolves the contradiction by combining the sustained release capability of PMMA with the bone regeneration capability of hydroxyapatite, eliminating the need for separate materials for each function.

Inventive Principle:

Principle #40Composite materials

2Reliability

If long-term systemic antibiotics are administered, then bacterial infections can be treated, but serious toxicities and selection of antibiotic-resistant bacteria occur

Engineering Contradiction:

Improveinfection treatment efficacyVSAvoidtoxicity and bacterial resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent implements local quality by delivering antibiotics directly to the infection site through the PMMA-bead composite material. The antibiotics are released locally at the infection site rather than being distributed systemically throughout the body. This localized delivery achieves effective infection treatment while minimizing systemic toxicity and reducing the selection pressure for antibiotic-resistant bacteria.

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent utilizes the porous structure of the PMMA beads to control antibiotic release. The porous nature of the beads allows for sustained release of antibiotics over time, maintaining effective concentrations at the infection site without requiring high systemic doses. This controlled release mechanism reduces both toxicity and the development of bacterial resistance.

Inventive Principle:

Principle #31Porous materials

3Reliability

If bacteria reside within biofilms, then they are sheltered from treatment, but treatment efficacy is limited

Engineering Contradiction:

Improvetreatment efficacyVSAvoidbiofilm protection

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent employs continuous release of antibiotics from the PMMA-bead composite material to maintain effective concentrations over an extended period. This continuous action allows the antibiotics to penetrate and eradicate bacteria within biofilms, which are otherwise protected from intermittent or single-dose treatments. The sustained release ensures that therapeutic levels are maintained long enough to disrupt biofilm structure and eliminate sheltered bacteria.

Inventive Principle:

Principle #20Continuity of useful action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves a high local concentration of antibiotics, reducing bacterial resistance and biofilm formation, while providing effective treatment for deep bone infections with sustained release properties and improved bone regeneration.

Implementation Method 1

Methodology Applied

Scientific EffectSustained release:

Implementation Method 2

biphasic ceramic material, such as hydroxyapatite combined with calcium sulphate, which is finely divided into micro or nanoparticles

Methodology Applied

Scientific EffectDegradation: Decomposition (biological)

Implementation Method 3

which is finely divided into micro or nanoparticles to provide a high effective surface area

Methodology Applied

Scientific EffectHigh surface area:

Implementation Method 4

achieving high local antibiotics levels at minimum inhibitory concentration (MIC) or minimum biofilm eradication concentration (MBEC)

Methodology Applied

Scientific EffectMinimum inhibitory concentration:

Data Source

PatentUS20250152661A1Novel combination treatment regimen of bacterial infections

Publication Date: 2025.05.15 BONE SUPPORT AB

AI summary

Present invention relates to a novel composition and treatment regimen in treatment of bacterial infections.