Formula A Compound for Hepatic Regeneration
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Solution Overview
Problem
Current methods for promoting hepatic regeneration in patients with reduced liver function are limited in effectiveness, and there is a need for improved strategies to enhance hepatocyte proliferation and liver mass, particularly in cases of liver failure due to chronic or acute conditions, where liver transplantation is often the only treatment option.
Innovation Solution
Administration of a therapeutically effective amount of a compound of formula (A), which includes specific structural components such as alkyl groups and functional moieties, to accelerate, promote, or increase hepatic regeneration in subjects with reduced liver function, thereby enhancing liver mass and functional recovery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liver transplantation is performed to treat liver failure, then liver function is restored, but availability of human hepatocytes and liver tissue is limited
Solution Approach 1:
The invention enables the patient's own liver to regenerate and restore function through pharmacological induction of hepatocyte proliferation, eliminating the need for external donor tissue. The liver serves itself by multiplying its own cells in response to the therapeutic compound.
2Productivity
If therapeutic agents are used to promote hepatic regeneration, then hepatocyte proliferation is stimulated, but effectiveness in-vivo is limited
Solution Approach 1:
The invention modifies the chemical structure of known hepatic mitogens by introducing specific substituents (R1=C1-C6 alkyl, R4=CO2H, C(O)NH(CH2)mSO3H, C(O)NH(CH2)nCO2H, or OSO3H) to enhance their pharmacological properties and in-vivo effectiveness while maintaining their ability to stimulate hepatocyte proliferation.
3Object-generated harmful factors
If major liver resection is performed to treat hepatic malignancies, then tumor is removed, but remaining functional liver mass is insufficient
Solution Approach 1:
The invention administers the therapeutic compound before or after liver resection to pre-stimulate or accelerate hepatocyte proliferation, ensuring that sufficient functional liver mass regenerates in the critical period following surgery when the liver is most vulnerable.
Data Source
AI summary
The present invention relates to methods of accelerating, promoting or increasing hepatic regeneration, or increasing liver mass in a subject, by using a compound of formula (A): or a pharmaceutically acceptable salt thereof, and wherein R1, R2, R3, R4, R5, R6, m, and n are as described herein.