Beta-Casein Prebiotic Composition for Infant Gut Microbiota

The patent applies parameter changes by modifying the protein composition parameter - specifically using beta-casein with proline at position 67 instead of conventional proteins. This amino acid substitution creates a novel protein structure that synergistically enhances the growth of beneficial bacteria when combined with prebiotics, thereby improving gut microbiota development without compromising basic nutrition

The patent employs composite materials by combining beta-casein (with specific proline-containing sequence) and prebiotics in a defined formulation. This composite nutritional composition creates a synergistic effect where the protein and prebiotics work together to selectively promote beneficial bacteria growth, addressing the limitation of conventional single-component nutritional formulations

The patent applies local quality by creating a targeted nutritional environment that selectively promotes beneficial bacteria while suppressing pathogenic bacteria. The beta-casein with proline at position 67, when combined with prebiotics, creates a localized favorable condition for Lactobacillus and Bifidobacterium growth in the gut, without providing the same advantage to pathogenic species

The patent converts the potential harm of formula feeding (which typically increases pathogenic bacteria) into a benefit by using a specially designed protein-prebiotic combination. This formulation transforms the nutritional provision function into a dual function that also actively suppresses pathogenic bacteria while promoting beneficial ones, thereby converting the harmful effect into a protective one