Mixed Allergen Compositions for Immune Tolerance Induction
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Solution Overview
Problem
Current treatments for food allergies, particularly in children, are inadequate in preventing the development of allergic reactions and are costly, with a significant number of children under 21 diagnosed with food allergies and associated healthcare costs exceeding $24 billion annually due to severe reactions like anaphylaxis.
Innovation Solution
Mixed allergen compositions comprising two or more different allergens, including nut, animal, and non-nut plant allergens, along with biotic agents and vitamins, are administered to subjects to inhibit symptoms and reduce the probability of developing food allergies, offering therapeutic and preventive applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for food allergies are used, then allergic reactions can be managed, but the treatments are inadequate in preventing the development of allergies and result in high healthcare costs
Solution Approach 1:
The patent applies preliminary action by administering mixed allergen compositions to infants and children before they develop food allergies. The composition includes multiple allergens (nut, animal, and non-nut plant allergens) that are introduced early in life to train the immune system, thereby preventing the development of allergic reactions rather than treating them after they occur. This preventive approach addresses the technical contradiction by improving reliability of allergy prevention while reducing the harmful factor of healthcare costs associated with treating established allergies.
2Reliability
If mixed allergen compositions are administered to reduce Th2 cell proliferation and IgE levels, then a non-allergenic state is induced, but the composition complexity increases
Solution Approach 1:
The patent merges multiple allergens into a single mixed composition that includes nut allergens, animal allergens, and non-nut plant allergens. This combination approach allows the formulation to provide broad-spectrum protection against various allergens simultaneously, improving reliability of allergy prevention. The merging of different allergen types into one composition simplifies the administration process compared to giving multiple separate allergen preparations, thereby addressing the technical contradiction between prevention effectiveness and composition complexity.
Solution Approach 2:
The mixed allergen composition exhibits multi-functionality by providing protection against multiple types of allergens (food, environmental, and animal) within a single formulation. This universal approach allows the composition to induce a non-allergenic state that is effective against a broad range of potential allergens, improving reliability of prevention while reducing the need for multiple separate treatments, thus addressing the complexity issue.
3Adaptability or versatility
If multiple allergens are included in the composition to provide broad-spectrum protection, then protection against allergens not present in the composition is achieved, but the manufacturing and administration complexity increases
Solution Approach 1:
The patent creates a universal allergen composition that provides multi-functional protection against various allergen types including nut, animal, and non-nut plant allergens. This universal formulation achieves broad-spectrum protection that adapts to different allergen challenges, improving versatility. The composition is designed to be administered as a single preparation, simplifying manufacturing and administration compared to multiple separate allergen formulations, thereby addressing the technical contradiction between versatility and ease of manufacture.
Data Source
AI summary
Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.