Biotissue Sampling Apparatus with Simultaneous Medicine Injection

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Solution Overview

Problem

Current biotissue sampling methods, such as gun biopsy, often cause hemorrhage and bruising, leading to potential contamination of tumor cells and difficulties in diagnosing fluid tumors, as they do not effectively manage hemorrhage or allow simultaneous tissue sampling and medicine injection.

Innovation Solution

A biotissue sampling apparatus with a storage unit for solid tissue, an aspirating hole for fluid tissue, and an injecting hole for medicine administration, allowing simultaneous tissue sampling and medicine injection to prevent hemorrhage and contamination, featuring a needle assembly with a cutting unit and a housing with a firing button for precise tissue sampling and medicine delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a needle assembly is inserted and extracted from a body for tissue sampling, then tissue can be obtained for diagnosis, but hemorrhage and bruising occur in the inserting hole

Engineering Contradiction:
Improvetissue sampling accuracyVSAvoidhemorrhage and bruising
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary anti-action by injecting medicine into the inserting hole before or during tissue sampling to prevent hemorrhage and bruising. The medicine injection creates a counter-effect that stops blood vessels from bleeding excessively, thereby preventing the harmful effects of hemorrhage and bruising that would otherwise occur during needle insertion and extraction.

Inventive Principle:
Principle #9Preliminary anti-action

Solution Approach 2:

The patent merges tissue sampling and medicine injection into a single integrated apparatus. The needle assembly includes both a cutting unit for tissue sampling and an injecting hole for medicine delivery, allowing both functions to be performed simultaneously through one insertion, thereby reducing the number of punctures and minimizing hemorrhage and bruising.

Inventive Principle:
Principle #5Merging (Combining)

2Measurement precision

If a cutting needle is used to obtain more tissue sample, then diagnosis accuracy is improved, but hemorrhage area increases and may be regarded as contamination

Engineering Contradiction:
Improvediagnosis accuracyVSAvoidhemorrhage area and contamination risk
Core Design Contradiction:
Measurement precisionVSObject-generated harmful factors

Solution Approach 1:

The patent applies preliminary anti-action by injecting medicine into the hemorrhage area caused by cutting needle insertion. The medicine is delivered through the injecting hole located in the needle assembly, which targets the bleeding area directly. This prevents the hemorrhage from expanding and reduces the risk of tumor cell contamination in the blood pool.

Inventive Principle:
Principle #9Preliminary anti-action

Solution Approach 2:

The patent converts the harmful hemorrhage area into a beneficial treatment opportunity by injecting medicine directly into the bleeding region. The same needle assembly that causes hemorrhage through cutting also delivers the medicine that treats the hemorrhage and prevents contamination, turning a negative effect into a positive therapeutic outcome.

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

3Adaptability or versatility

If a traditional biopsy apparatus is used, then solid tissue can be sampled, but fluid tissue sampling is difficult

Engineering Contradiction:
Improvetissue type adaptabilityVSAvoidfluid tissue sampling ease
Core Design Contradiction:
Adaptability or versatilityVSEase of operation

Solution Approach 1:

The patent applies universality by designing a needle assembly that can handle both solid and fluid tissues. The cutting unit effectively samples solid tissues, while the injecting hole can aspirate and sample fluid tissues. This multi-functional design allows the same apparatus to adapt to different tissue types without requiring separate devices.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent segments the sampling functions into two distinct components: a cutting unit for solid tissue and an injecting hole for fluid tissue. This segmentation allows each component to be optimized for its specific function while being integrated into a single needle assembly, making the apparatus versatile for different tissue types.

Inventive Principle:
Principle #1Segmentation

4Object-affected harmful factors

If medicine injection is performed separately from tissue sampling, then hemorrhage can be treated, but additional punctures increase contamination risk

Engineering Contradiction:
Improvehemorrhage treatmentVSAvoidcontamination risk from additional punctures
Core Design Contradiction:
Object-affected harmful factorsVSObject-generated harmful factors

Solution Approach 1:

The patent merges tissue sampling and medicine injection into a single integrated procedure. The needle assembly includes both the cutting unit for tissue sampling and the injecting hole for medicine delivery, allowing both functions to be performed through one insertion. This eliminates the need for additional punctures that would otherwise be required for separate medicine injection, thereby reducing contamination risk.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The needle assembly is designed as a universal tool that performs multiple functions: tissue cutting, tissue sampling, and medicine injection. This multi-functionality allows hemorrhage treatment to be performed through the same insertion used for tissue sampling, avoiding additional punctures and the associated contamination risk.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus enables accurate and simultaneous tissue sampling and medicine injection, reducing hemorrhage and contamination risks, and facilitates easier diagnosis by allowing medicine to be applied to the biopsy track and tumor region, improving the accuracy of tumor tissue sampling regardless of tissue type.

Implementation Method 1

an aspirating hole configured to sample a fluid tissue

Methodology Applied
Scientific EffectSuction: Suction

Implementation Method 2

an injecting hole configured in a lower unit of a tube injecting medicine in a tissue with a wound

Methodology Applied
Scientific EffectPressure-driven flow: Pressure Gradient

Data Source

PatentUS10695039B2Biotissue sampling apparatus
Publication Date: 2020.06.30 NATIONAL CANCER CENTER(JP)
  • US10695039B2 patent drawing
  • US10695039B2 patent drawing
  • US10695039B2 patent drawing

AI summary

The following description provides a biotissue sampling apparatus comprising a housing, a firing button configured on a rear-end of the housing; a tube with an aspirating hole configured to inject medicine in a tissue according to a longitudinal direction of a lower end and extended from a front-end of a housing; and a needle assembly that may move from the tube to a biopsy region by a button thereby cut a solid tissue and store or aspire a fluid tissue.