Bipolar High-Voltage Pulsing for Precise Tissue Ablation
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Solution Overview
Problem
Existing tissue ablation systems struggle to precisely control ablation to desired tissues while avoiding damage to surrounding healthy tissue, particularly in cardiac applications.
Innovation Solution
Bipolar high voltage pulsing systems and devices that generate high voltage bipolar pulses with specific pulse patterns and frequencies, combined with controlled electrode configurations, to achieve targeted electroporation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high voltage pulses are delivered to achieve tissue ablation, then ablation effectiveness is improved, but damage to surrounding healthy tissue increases
Solution Approach 1:
The system delivers periodic bipolar pulses with alternating positive and negative phases at controlled repetition frequencies (10-1000 Hz). This periodic action allows the tissue to recover between pulses while maintaining cumulative ablation effect, improving precision by limiting damage to only the targeted tissue exposed to the electric field
Solution Approach 2:
The system dynamically adjusts pulse parameters including voltage amplitude (±100 to ±1000 V), pulse width (1-1000 μs), and repetition frequency based on real-time feedback from impedance measurements and temperature sensors. This enables precise control of the ablation zone boundaries, ensuring effective treatment while protecting surrounding healthy tissue
2Productivity
If pulse repetition frequency is increased to improve ablation speed, then productivity is improved, but control precision deteriorates
Solution Approach 1:
The system incorporates real-time feedback from impedance measurements and temperature sensors to dynamically adjust pulse delivery parameters. This feedback loop maintains control precision even at high repetition frequencies by preventing overheating and ensuring the ablation boundary remains within the target zone
Solution Approach 2:
The system allows dynamic adjustment of pulse repetition frequency during the ablation procedure, transitioning between higher frequencies for rapid ablation and lower frequencies for precision control. This dynamic adaptability enables the system to optimize both productivity and control precision based on real-time treatment conditions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances the precision and consistency of tissue ablation by selectively inducing reversible electroporation in targeted tissues, minimizing damage to surrounding healthy tissue.
Implementation Method 1
Tissue ablation, however, needs to be controlled to not destroy surrounding healthy tissue. Accordingly, there is a need for ablation systems, devices, and methods that can provide be controlled to limit ablation to desired tissues and/or locations.
Implementation Method 2
Bipolar high voltage pulsing ablation systems, devices, and methods are disclosed that include a power supply that can produce high voltage bipolar pulses with a positive high voltage pulse greater than about 200 V followed by a negative high voltage pulse less than about −200 V
Data Source
AI summary
Bipolar high voltage bipolar pulsing ablation systems, devices, and methods are disclosed that include power supplies that can produce high voltage bipolar pulses with a positive high voltage pulse greater than about 200 V followed by a negative high voltage pulse less than about −200 V with a positive to negative dwell period between the positive high voltage pulse and the negative high voltage pulse. A high voltage bipolar pulsing power supply, for example, can reproduce high voltage pulses with a pulse repetition frequency greater than about 10 kHz.