Reabsorbable Bone Void Filler Composition for Strength and Bone Regrowth
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Solution Overview
Problem
Existing bone defect treatments lack a material that provides high compressive strength and rapidly absorbs to transform into bone, offering improved structural support and healing.
Innovation Solution
A bio-material composition comprising MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, and calcium sodium phosphosilicate, mixed with an aqueous solution to form a reabsorbable slurry, which is osteoconductive and osteoinductive, enabling new bone growth and rapid transformation into bone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a bone void filler material is used to treat bone defects, then the bone structure is supported and healing is promoted, but the material must balance structural strength with absorption rate to prevent cortical bone deterioration
Solution Approach 1:
The patent applies parameter changes by modifying the chemical composition parameters of the bone void filler material. Specifically, it uses a controlled ratio of calcium phosphate to magnesium carbonate (within 2:1 to 10:1 range) and adjusts particle size distribution (mixing fine particles <63 micrometers with coarser particles) to achieve optimal balance between compressive strength and absorption rate. This compositional parameter optimization allows the material to provide structural support while absorbing at a controlled rate that promotes bone healing without causing cortical bone deterioration.
Solution Approach 2:
The patent employs composite materials by combining calcium phosphate and magnesium carbonate in specific ratios within the bone void filler composition. This composite approach leverages the complementary properties of both materials: calcium phosphate provides osteoconductivity and structural framework, while magnesium carbonate enhances compressive strength and controls degradation rate. The composite formulation also includes additional components such as growth factors, osteoinductive agents, and anti-inflammatory medications to create a multifunctional material that simultaneously addresses strength requirements and controlled absorption needs.
2Productivity
If the bone void filler material absorbs rapidly to turn into bone, then bone strength is improved faster, but the material may lack sufficient structural support during the absorption period
Solution Approach 1:
The patent applies preliminary action by incorporating osteoinductive agents and growth factors into the bone void filler material before implantation. These pre-loaded bioactive components immediately stimulate osteoblast activity and bone formation processes upon contact with the bone defect site, accelerating bone regeneration without requiring waiting periods. The material is pre-formulated with specific concentrations of BMPs (bone morphogenetic proteins), VEGF (vascular endothelial growth factor), and other osteoinductive substances that trigger rapid bone formation while the material maintains its structural integrity.
Solution Approach 2:
The patent uses parameter changes by controlling the particle size distribution and surface area-to-volume ratio of the bone void filler components. By mixing fine particles ( <63 micrometers) with coarser particles in optimized ratios, the material increases its surface area for cellular interaction and biochemical reactions, thereby accelerating bone formation speed. Simultaneously, the coarser particles maintain the structural framework and compressive strength during the absorption period, resolving the contradiction between rapid bone formation and structural support.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bio-material slurry provides enhanced bone structure by rapidly absorbing and turning into bone, stimulating osteoblast activity and improving bone strength and integrity.
Implementation Method 1
the reabsorbable bio-material slurry is osteoconductive and osteoinductive, thereby enabling new bone growth in the void
Implementation Method 2
the reabsorbable bio-material slurry is osteoconductive and osteoinductive, thereby enabling new bone growth in the void
Implementation Method 3
mixing a dry potassium phosphate based mixture with an aqueous solution to form a reabsorbable bio-material slurry
Implementation Method 4
the reabsorbable bio-material slurry breaks down faster in the bone defect area and rapidly turns into bone to provide improved strength
Data Source
AI summary
The present disclosure relates to a method for treating a bone defect using a bio-material with increased porosity and reabsorption characteristics, the method comprising: (a) mixing a dry potassium phosphate based mixture with an aqueous solution to form a reabsorbable bio-material slurry, wherein the dry potassium phosphate based mixture comprises MgO, monobasic potassium phosphate, monobasic sodium phosphate, proteoglycans, and calcium sodium phosphosilicate, wherein a weight percent ratio of monobasic potassium phosphate to MgO is between about 3:1 and 1:1, wherein the dry potassium phosphate based mixture is configured to be mixed with the aqueous solution to thereby form a reabsorbable bio-material slurry, wherein the proteoglycans are between about 1-10 weight percent of the dry composition, (b) accessing a void of a bone defect within a bone, and (c) filling the void with the reabsorbable bio-material slurry, wherein the reabsorbable bio-material slurry is osteoconductive and osteoinductive, thereby enabling new bone growth in the void.