Calcium Phosphate Carrier Stabilizes Vitamin D Against Oxidation
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Solution Overview
Problem
Existing compositions for human and animal nutrition and pharmaceuticals face challenges in stabilizing active compounds like vitamin D, which are prone to oxidation and isomerization, and struggle with homogeneous dispersion and long-term stability.
Innovation Solution
A stable solid composition is developed using a calcium phosphate carrier with low water solubility and a hydrophobic stabilizer, such as C3-22 fatty acids or their ester derivatives, to enhance the stability and dispersion of oil-soluble active components like vitamins and antioxidants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If active compounds are dissolved or dispersed in liquid solvent and coated on particulate materials, then incorporation in food and bioassimilation are improved, but stability in time deteriorates due to oxidation and isomerization
Solution Approach 1:
The patent changes the physical state parameter from liquid solvent to solid carrier (particulate material), and modifies the chemical environment by selecting specific carriers (silica, calcium carbonate, calcium phosphate) with different surface properties and solubilities. This parameter change transforms the formulation from a liquid-based coating to a solid adsorbate system, improving stability while maintaining ease of incorporation
Solution Approach 2:
The patent creates composite formulations by combining active compounds with stabilizers (antioxidants, emulsifiers) and carriers (silica, calcium carbonate, calcium phosphate). These composite materials provide synergistic effects where the carrier provides structural support and adsorption, stabilizers prevent oxidation and isomerization, and the combination achieves both ease of incorporation and long-term stability
2Manufacturing precision
If small amounts of active compound are added to composition, then dosage precision is improved, but homogeneous dispersion deteriorates
Solution Approach 1:
The patent utilizes porous particulate carriers (silica, calcium carbonate, calcium phosphate) that provide high surface area and porous structure for adsorption. These porous materials can effectively adsorb small amounts of active compounds throughout their structure, ensuring homogeneous dispersion even at low concentrations while maintaining precise dosage control
Solution Approach 2:
The patent introduces stabilizers as intermediary substances between the active compound and the carrier matrix. These stabilizers (antioxidants, emulsifiers) facilitate uniform distribution of the active compound within the composition, preventing aggregation and ensuring homogeneous dispersion while maintaining dosage precision
3Reliability
If active compounds are stabilized by mixing with stabilizer and coating material, then stability is improved, but complexity of manufacture increases
Solution Approach 1:
The patent combines multiple functions into a single integrated system: the carrier provides adsorption and structural support, stabilizers provide oxidation protection and emulsification, and the formulation achieves homogeneous dispersion. This merging of functions into a unified particulate composition simplifies the manufacturing process compared to separate coating and stabilization steps
Solution Approach 2:
The patent simplifies manufacturing by changing the formulation approach from liquid coating to solid-state adsorption. The active compound is directly adsorbed onto the particulate carrier in solid form, eliminating complex coating processes, drying steps, and equipment requirements associated with liquid application methods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively prevents oxidation and maintains the stability of active components like vitamin D for extended periods, significantly improving their shelf life and bioavailability.
Implementation Method 1
a stable solid composition comprising a first carrier and an adsorbate adsorbed thereon
Implementation Method 2
contributes to the enhancement of the stability of the said at least one active component, e.g., by preventing oxidation thereof
Data Source
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AI summary
The present invention relates to stable solid compositions comprising a first carrier and an adsorbate comprising at least one active component such as a vitamin D derivative and a hydrophobic stabilizer thereof, characterized in that said first carrier is a calcium phosphate or derivatives thereof having a solubility in water lower than 0.1 wt% at room temperature.