Organic Active Ingredients TRIZ Cases

Tetrahydroisoquinoline derivatives inhibit NHE-mediated antiport to reduce systemic sodium levels.

A heterocyclic compound inhibits cholesterol 24-hydroxylase activity.

Selective deuteration extends the biological half-life of alanine derivatives, reducing dosing frequency for neurological disease treatment.

A fenfluramine formulation excludes digestible carbohydrates to reduce cravings and promote adherence to a ketogenic diet.

Glyceryl esters hydrolyze to sustain sodium benzoate levels, reducing dosing frequency and adverse effects in glycine encephalopathy.

Merging buprenorphine with Compound-1 blocks μ-opioid receptor overactivation, preventing dependency while maintaining analgesic efficacy.

A remote loading method encapsulates sparingly water-soluble drugs into liposomes using a transmembrane electrochemical gradient.

Indoleacetic acid derivatives degrade GATA3 to restore erythropoietin synthesis, eliminating expensive protein injections for anemia therapy.

Eutectic ibuprofen mixtures with benzoic acid reduce capsule volume while maintaining therapeutic profile and solubility.

Synthetic imidazolyl tricyclic enones deliver antioxidant and anti-inflammatory activity through targeted molecular design.

Combining FGFR and cMet inhibitors delays tumor resistance emergence by blocking alternative Met signaling pathways during therapy.

API-1 exploits local quality differences to inhibit hyperactivated Akt in tumors while sparing normal cells, reducing systemic toxicity.

Marker gene replacement resolves low efficiency and confirmation difficulties in vaccinia virus gene introduction.

Hydroxamic acid moieties bind metal ions to crosslink the micelle core, preventing premature dissociation during drug delivery.

Acidifying lactose solutions to pH 2-5 inhibits isomerization into lactulose during sterilization, preserving product purity.

Novel 5-fluorouracil derivative with dual enzymatic activity overcomes rapid decomposition and cytotoxicity to improve therapeutic outcomes.

Heteroaromatic macrocyclic ether compounds inhibit ROS1 and ALK kinases with high specificity.

Dynamin inhibitors prevent Porphyromonas gingivalis entry into host cells, treating periodontitis by blocking intracellular survival mechanisms.

Deuterium substitution strengthens carbon bonds to enhance metabolic stability, reducing toxic metabolite formation and improving pharmacokinetic properties.

Selective N-substituted indole derivatives block EP2 receptors to inhibit tumor growth and inflammation while sparing cardiovascular pathways.

Pre-conditioning with genistein scavenges reactive oxygen species, preventing oxidative stress and erectile dysfunction during prostate cancer radiotherapy.

Crosslinked carboxymethylcellulose forms a stomach gel to delay glucose absorption, treating obesity and diabetes.

Specific probiotic strains colonize the vagina to lower pH via lactic acid, preventing dysbiosis and infection risk.

Liquid levothyroxine formulation eliminates reconstitution contamination risk by maintaining pH between 9.0 and 11.5 with tromethamine.

Segmented synthesis of (R,S)-nicotine from nicotinate ester removes carcinogenic contaminants while maintaining high purity.

A maleimide derivative inhibits GSK3β kinase activity to induce apoptosis in cancer cells.

Substituted pyrrole compounds selectively inhibit checkpoint kinase 1 to enhance tumor cell death while sparing normal cells.

Segmenting receptor subtypes allows compounds to target alpha2 and alpha3 GABAA receptors, reducing sedation associated with traditional benzodiazepines.

AAV5 vectors deliver double-stranded RNA to suppress mutant huntingtin expression, avoiding repeated dosing and off-target effects.

Pyrazole derivatives selectively target CB2 receptors to treat pain and inflammation without triggering psychotropic side effects.

Handheld nanophotonic assay detects RNA expression levels from circulating immune cells to diagnose lower respiratory infections.

Specific oligosaccharide mixtures reduce NEC incidence by promoting gut maturation without probiotic safety risks.

Cyclodextrins solubilize paracetamol in aqueous media while antioxidants prevent chemical degradation that causes hepatotoxic compounds.

A stretchable sleeve uses a perforated section to apply medication through the material for direct skin contact.

Long chain fatty acids repress virulence genes to inhibit Salmonella invasion, avoiding antibiotic resistance development.

Applying vitamin D in medium-chain triglycerides to a pacifier resolves dosing reliability issues caused by spitting during direct mouth administration.

Tradipitant treats gastroparesis in SLC15A4 variant carriers, avoiding metoclopramide side effects.

Segmented synthesis of hepatitis B compounds eliminates column purification and chiral separation, resolving low yield bottlenecks.

Amphiphilic carriers stabilize 50-950 nm particles to extend shelf-life while maintaining mouthfeel.

A pharmaceutical composition combining pregabalin and riluzole in a fixed ratio to treat neuropathic pain.

Vacuum packaging prevents air pockets in lyophilized embolic microspheres, ensuring stable suspension and fast rehydration during embolization.

Purified miRNA-enriched acellular preparations overcome regulatory T cell suppression to enhance anti-tumor responses and cytokine secretion.

Analyzing serum amyloid P levels before and after vascular disrupting agent administration to predict patient response.

Assessing GULP1 promoter methylation enables early urothelial cancer detection, addressing insufficient diagnostic precision and high recurrence rates.

A calcium phosphate carrier adsorbs hydrophobic stabilizers to protect vitamin D derivatives in solid compositions.

A thymol ester composition reduces melanocyte cellular senescence biomarkers to reverse UV-induced morphological changes.

Silica gel desiccant in press-on nails dehydrates fungi to shorten healing periods compared to traditional chemical treatments.

3-(3-[1,2,4]-triazolo)-oxatriazolium-5-olate activates soluble guanylate cyclase to increase cGMP synthesis.

Alkylated benzimidazolone compounds resolve unpredictable gel properties by forming stable organogels via hierarchical self-assembly.