Camera-Based Drug Container Inspection System

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Solution Overview

Problem

Current quality control inspection methods for drug containers are slow and wasteful, often resulting in the unnecessary discard of containers and drug products due to the tedious nature of liquid rinsing and filtering, which can lead to false positives and limited inspection capacity.

Innovation Solution

An inspection system utilizing a camera device coupled with a robot that captures series of images of the interior surfaces of drug containers, processed by a control circuit to identify foreign matter, allowing for non-contact, automated inspection and reducing the risk of artefacts.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If liquid rinsing and filtering method is used for inspection, then foreign matter can be detected, but inspection speed is slow and productivity is limited

Engineering Contradiction:
Improveforeign matter detection capabilityVSAvoidinspection speed
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent replaces the mechanical liquid rinsing and filtering system with an optical imaging system using a camera device. The camera captures images of the container interior surface, and a control circuit processes these images to detect foreign matter, eliminating the need for physical rinsing and filtering operations while maintaining detection capability and significantly improving inspection speed

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent creates an optical copy (image) of the container interior surface instead of physically interacting with it through rinsing. The camera device captures visual information that replicates the appearance of the interior surface, allowing foreign matter detection through image analysis rather than physical filtration

Inventive Principle:
Principle #26Copying

2Measurement precision

If liquid rinsing method is used for inspection, then foreign matter can be identified, but false positives occur and containers are unnecessarily discarded

Engineering Contradiction:
Improveforeign matter identification accuracyVSAvoidcontainer discard rate
Core Design Contradiction:
Measurement precisionVSLoss of substance

Solution Approach 1:

The patent replaces the liquid rinsing method with an optical imaging and image processing system. The control circuit analyzes captured images to distinguish actual foreign matter from artifacts or rinsing residues, providing more accurate identification and reducing false positives that lead to unnecessary container discards

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces an intermediary image processing step between the inspection action and the detection result. The control circuit processes the captured images to differentiate between genuine foreign matter and artifacts caused by the inspection process itself, thereby reducing false positives

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If manual inspection method is used, then detailed examination is possible, but the process is tedious and time-consuming

Engineering Contradiction:
Improveinspection detail capabilityVSAvoidinspection time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent replaces manual visual inspection with an automated optical imaging system. The camera device captures high-resolution images of the container interior, and the control circuit automatically processes these images to identify foreign matter, eliminating the tedious manual examination process while maintaining or improving inspection detail capability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent enables the inspection system to perform self-service through automation. The camera device and control circuit work together to automatically capture, process, and analyze images without human intervention, eliminating the time-consuming manual inspection process while maintaining detailed examination capability

Inventive Principle:
Principle #25Self-service

4Productivity

If camera-based inspection is implemented, then inspection speed increases, but system complexity increases

Engineering Contradiction:
Improveinspection speedVSAvoidsystem complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent employs a multi-functional integrated system where a single camera device performs multiple functions: capturing images, providing illumination through integrated light sources, and enabling various inspection angles through robotic positioning. This universal approach increases inspection speed while managing system complexity through functional integration rather than multiple separate components

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enables faster inspection of more containers, reduces false positives, and minimizes the discard of both containers and drug products, improving quality control and compliance by effectively identifying foreign matter without the need for fluid rinsing.

Implementation Method 1

a camera device (14) having a lens (38)... configured to capture a series of images of an interior surface of a sidewall and/or bottom wall of the drug container

Methodology Applied
Scientific EffectLight reflection: Reflection

Data Source

PatentEP3775857B1Camera-based drug container inspection
Publication Date: 2023.07.05 AMGEN INC
  • EP3775857B1 patent drawingFigure 1
  • EP3775857B1 patent drawingFigure 2
  • EP3775857B1 patent drawingFigure 3A~3C

AI summary

An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.