Carglumic Acid DMSO Solvate Purification for High Yield
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Solution Overview
Problem
Existing methods for purifying carglumic acid are time-consuming, costly, and result in high waste generation with low yield, achieving only up to 99% purity, which is insufficient for commercial viability.
Innovation Solution
A method involving the formation of a carglumic acid solvate with dimethyl sulfoxide, followed by precipitation and subsequent release using solvents or acids, allowing for high-purity carglumic acid production through simple and cost-effective procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If repeated precipitation and crystallizations are used to purify carglumic acid, then purity increases to 99%, but processing time increases and yield decreases
Solution Approach 1:
The invention changes the chemical parameter by forming a solvate complex with dimethyl sulfoxide, which fundamentally alters the purification mechanism. Instead of relying on repeated precipitation and crystallization steps, the solvate formation allows for direct filtration to achieve high purity (99.5-99.7%) in a single operation, dramatically reducing processing time while maintaining high yield
Solution Approach 2:
The invention introduces dimethyl sulfoxide as an intermediary substance that forms a solvate complex with carglumic acid. This intermediary enables the purification process to work through a different mechanism - the solvate complex precipitates selectively from the reaction mixture, allowing direct filtration to obtain high-purity product without requiring multiple repeated purification cycles
2Manufacturing precision
If repeated precipitation and crystallizations are used to purify carglumic acid, then purity increases to 99%, but waste generation increases
Solution Approach 1:
The invention changes the purification approach by utilizing solvate formation with dimethyl sulfoxide, which enables single-step filtration to achieve 99.5-99.7% purity. This eliminates the need for multiple repeated purification cycles, thereby significantly reducing waste generation while maintaining high product purity and yield
3Manufacturing precision
If repeated precipitation and crystallizations are used to purify carglumic acid, then purity increases to 99%, but yield decreases
Solution Approach 1:
The invention changes the purification mechanism through solvate formation with dimethyl sulfoxide, enabling direct filtration to achieve high purity (99.5-99.7%) in one step. This approach avoids the yield loss associated with multiple repeated purification cycles, maintaining high productivity while delivering superior purity
4Manufacturing precision
If conventional purification methods are used, then 99% purity is achieved, but the process is complex and costly
Solution Approach 1:
The invention introduces dimethyl sulfoxide as an intermediary that forms a solvate complex with carglumic acid, enabling purification through simple filtration. This single-step process replaces complex multi-step procedures involving repeated precipitation and crystallization, dramatically simplifying the overall process while achieving 99.5-99.7% purity
Solution Approach 2:
The invention changes the fundamental approach to purification by utilizing solvate formation, which transforms a complex multi-step process into a simple single-step filtration operation. This parameter change in the purification mechanism reduces process complexity and cost while maintaining high purity levels
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves high yields and purities exceeding 99.5%, reducing processing time and waste, while maintaining operational efficiency.
Implementation Method 1
when the raw carglumic acid is dissolved in dimethyl sulfoxide and solvate of carglumic acid and dimethyl sulfoxide is formed
Implementation Method 2
A solvent, in which the solvate of carglumic acid with dimethyl sulfoxide is insoluble, is then added to the generated solution, thereby precipitating the solvate of carglumic acid with dimethyl sulfoxide
Data Source
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AI summary
Method of purification of carglumic acid, substance formula I, contains the following steps: a) Dissolution of carglumic acid in dimethyl sulfoxide; b) Addition of a precipitation solvent; c) Isolation of the precipitated solvate of carglumic acid with dimethyl sulfoxide; d) Release of carglumic acid from the solvate by the help of water, possibly a mixture of water and an organic solvent, possibly a mixture of water and an organic or mineral acid, possibly a mixture of water, an organic acid and a mineral acid, possibly by an activity of an organic acid, possibly by an activity of mixture of water, a mineral acid and an organic solvent.