Cell Memory Erasure via Nucleic Acid Inactivation

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing methods for altering cell properties often rely on mutagens, gene editing tools, or changing environmental conditions, which can be invasive and have limitations.

Innovation Solution

A method to control cell properties using products that inactivate or alter nucleic acid molecules (NAMACS, NAMACS-ANA, and TEZRs) without introducing genes, through treatments with DNA and RNA inactivating agents, under controlled growth conditions, to achieve specific cellular states like 'Cut', 'Zero', or 'Y' states.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Loss of information

If genes are introduced into cells by transformation or transduction, then new genetic information is added to cells, but the process becomes invasive and complex

Engineering Contradiction:

Improvegenetic informationVSAvoidgene introduction process

Core Design Contradiction:

Loss of informationVSDevice complexity

Solution Approach 1:

The invention extracts and targets specific nucleic acid molecules (NAMACS, NAMACS-ANA, TEZRs) that carry genetic information or regulate gene expression. By using inactivating agents that specifically bind to and neutralize these molecules, the patent achieves genetic information control without introducing foreign genes or using complex gene editing machinery, thus resolving the contradiction between information modification and process complexity

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces intermediary substances (inactivating agents such as antibodies, aptamers, or small molecules) that mediate the control of cellular properties by binding to target nucleic acids. These intermediaries enable precise regulation of gene expression and cellular behavior without direct genetic manipulation, simplifying the overall process while achieving the desired genetic information control

Inventive Principle:

Principle #24Intermediary (Mediator)

2Manufacturing precision

If genome editing molecules are introduced to cut and sew genes, then cell properties are changed, but the process requires special gene editing tools and is highly invasive

Engineering Contradiction:

Improvecell property alterationVSAvoidinvasiveness

Core Design Contradiction:

Manufacturing precisionVSObject-affected harmful factors

Solution Approach 1:

Instead of using molecules to cut and sew genes (active modification), the invention inactivates or alters existing nucleic acid molecules (passive control). By targeting NAMACS, NAMACS-ANA, and TEZRs with inactivating agents, the patent achieves cell property alteration through inhibition or modulation rather than invasive cutting and rejoining, thereby maintaining precision while reducing harm

Inventive Principle:

Principle #13The other way round (Inversion)

Solution Approach 2:

The patent converts the potential harm of invasive gene editing into a beneficial approach by using inactivating agents that naturally bind to and neutralize target nucleic acids. This approach leverages the specificity of molecular recognition to achieve precise cell property control without the damaging effects of genomic cuts and repairs, turning a harmful invasive process into a benign regulatory mechanism

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Ease of operation

If environmental conditions are changed to control cell properties, then cell behavior is regulated, but the control is indirect and less precise

Engineering Contradiction:

Improvecell behavior controlVSAvoidcontrol precision

Core Design Contradiction:

Ease of operationVSMeasurement precision

Solution Approach 1:

The invention applies local quality by targeting specific nucleic acid molecules (NAMACS, NAMACS-ANA, TEZRs) within the cell rather than changing overall environmental conditions. The inactivating agents bind specifically to these localized targets, enabling precise control of particular genetic functions or pathways while leaving the rest of the cellular environment unchanged, thus achieving both ease of operation and high precision

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for precise regulation of cellular functions and behaviors without genetic modification, enabling applications in medicine, biotechnology, and other fields by altering signal transmission, gene expression, and cellular interactions.

Implementation Method 1

products can destroy and/or inactivate NAMACS and NAMACS-ANA

Methodology Applied

Scientific EffectEnzymatic degradation: Enzyme

Implementation Method 2

products can destroy and/or inactivate NAMACS and NAMACS-ANA

Methodology Applied

Scientific EffectEnzymatic degradation: Enzyme

Data Source

PatentUS20260097078A1Regulation of cells and organisms

Publication Date: 2026.04.09 TETS VICTOR

AI summary

The invention relates to medicine, biology, veterinary, pharmacology diagnostics, agriculture, ecology, meteorology, seismology, construction biotechnology, biomanufacturing and provided herein are products and methods for managing cells behavior, memory of cells and erasure of cell memory. The present invention describes products and methods that, unlike the known ones, make it possible to control the properties of cells and organisms without the use of mutagens and/or the special introduction of genes and/or use of specific gene tools and/or changing its environmental conditions.