Liquid Chromatograph Pump Timing Synchronization
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Solution Overview
Problem
Existing liquid chromatograph methods face challenges in maintaining accurate and reproducible analysis results due to pressure variations caused by sample injection and passage switching, which are not effectively controlled by existing technologies.
Innovation Solution
A liquid chromatograph apparatus and method that synchronizes the liquid transfer cycle of the pump with the sample injection operation, ensuring that these operations do not overlap with the intervals for obtaining pressure data, using a control section to manage the liquid transfer and autosampler operations based on pressure information.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If sample injection and passage switching operations are performed during liquid transfer, then analysis productivity is improved, but pressure variation occurs which degrades measurement precision
Solution Approach 1:
The control section schedules sample injection and passage switching operations to occur at predetermined timings that are separated from the pressure measurement timing. This preliminary scheduling ensures that operations which cause pressure variations do not coincide with pressure data acquisition, thereby maintaining measurement precision while still allowing these operations to be performed within the analysis cycle.
Solution Approach 2:
The system dynamically adjusts the timing of sample injection and passage switching operations relative to the liquid transfer cycle and pressure measurement. By making the operation timing flexible and synchronized with the liquid transfer phase, the system ensures that these operations occur during phases where pressure variations do not interfere with measurement accuracy.
2Loss of time
If liquid transfer velocity is increased, then analysis time is reduced, but pressure stability deteriorates
Solution Approach 1:
The system employs periodic liquid transfer operations with synchronized sample injection and passage switching at specific phases of the transfer cycle. By establishing a periodic rhythm where operations occur at predetermined intervals and phases, the system maintains pressure stability during measurement while achieving efficient overall analysis timing.
Data Source
AI summary
An analysis method is achieved in which pressure variation resulting from sample injection or passage switching by an autosampler does not exert an influence on the control of a liquid transfer pump. The liquid chromatograph analysis method comprises the steps of: transferring two or more types of eluents while changing a mixing ratio between the eluents; adjusting an amount of the transferred liquid within a predetermined time in a passage for the eluent transferred; injecting a sample in the passage; supplying to a separation column the eluent into which the sample is injected; separating a target component in the sample; and detecting the target component thus separated. In this method, control is exercised so as to synchronize a liquid transfer cycle of the eluent with the sample injecting operation and to implement the sample injecting operation at a timing rather than the pressure obtaining time.