Cellulosic-Coated Potassium Chloride for Consistent Sustained Release
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Solution Overview
Problem
Existing potassium chloride formulations struggle with inefficient sustained release profiles, high production costs, and inconsistent dosing accuracy, particularly in formulations for treating potassium deficiency.
Innovation Solution
A sustained release pharmaceutical composition comprising Potassium chloride crystals with a mesh size of 60 to 100 mesh coated with up to 9% cellulosic polymers, combined with pharmaceutically acceptable excipients, to achieve improved dissolution profiles and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional potassium chloride formulations (tablets or capsules) are used, then convenience and ease of administration are improved, but sustained release profile and dissolution control are insufficient
Solution Approach 1:
The potassium chloride crystals are pre-coated with cellulosic polymer before formulation into tablets or capsules. This preliminary coating action ensures that the sustained release mechanism is established before administration, allowing the convenient tablet/capsule form to deliver controlled release over time without requiring additional patient actions.
Solution Approach 2:
The invention changes the physical-chemical parameters of the potassium chloride formulation by using fine mesh size crystals (60-100 mesh) and coating them with a specific amount of cellulosic polymer (up to 9% w/w). These parameter changes transform the conventional immediate-release formulation into a sustained-release formulation while maintaining tablet or capsule dosage forms for ease of administration.
2Duration of action of moving object
If existing controlled release formulations are used, then sustained release is achieved, but production cost and manufacturing complexity increase
Solution Approach 1:
The invention optimizes manufacturing parameters by using fine mesh potassium chloride crystals (60-100 mesh) that require less polymer coating (up to 9% w/w) to achieve sustained release. This parameter optimization reduces material costs and simplifies the coating process compared to conventional formulations that require higher polymer amounts and more complex processing.
Solution Approach 2:
The use of fine mesh crystals (60-100 mesh) creates a porous structure that enhances polymer penetration and binding efficiency. This porous structure allows for more effective sustained release with lower polymer content, reducing manufacturing costs while maintaining the sustained release profile.
3Quantity of substance
If existing formulations are used, then potassium supplementation is provided, but dissolution profile consistency and bioavailability are insufficient
Solution Approach 1:
The invention applies local quality control by coating each potassium chloride crystal individually with cellulosic polymer. This ensures uniform drug release characteristics across all crystals in the formulation, leading to consistent dissolution profiles and reliable bioavailability. The fine mesh size (60-100 mesh) ensures uniform coating coverage on each particle.
Solution Approach 2:
By changing the crystal size parameter to fine mesh (60-100 mesh) and controlling the polymer coating amount (up to 9% w/w), the invention achieves optimal dissolution characteristics. These parameter changes ensure consistent drug release rates and improve bioavailability compared to conventional formulations with larger, less uniformly coated crystals.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition ensures sustained drug release, enhanced bioavailability, high content uniformity, and cost-effective, efficient manufacturing, facilitating large-scale production.
Implementation Method 1
the potassium chloride crystals are coated with a coating solution comprising cellulosic polymer... exhibits an advantageous dissolution profile
Data Source
AI summary
The present invention relates to sustained release formulations of Potassium chloride crystals having a mesh size ranging from about 60 to 100 mesh, combined with one or more pharmaceutically acceptable excipients, wherein the potassium chloride crystals are coated with a coating solution comprising cellulosic polymer in an amount up to 9% w/w based on the total weight of the granules and to processes for their preparation.