Pill Delivery TRIZ Cases
- Film-Coated Empagliflozin-Metformin Tablet With Sodium Stearyl Fumarate
Sodium stearyl fumarate improves flowability, compressibility, homogeneity, and dissolution in a film-coated empagliflozin-metformin tablet.
- Polymer-Coated CO2 Absorbent Composition for Respiratory Hypercapnia
A biocompatible polymer coating lets oral CO2 absorbents lower body carbon dioxide without the toxicity of caustic in vivo scrubbers.
- AT1R Blocker and CCR2 Inhibitor Combination for Kidney Fibrosis
By targeting both renin-angiotensin and chemokine pathways, this combination therapy reduces monocyte-driven inflammation and kidney fibrosis.
- CFTR Modulator Combination for F508del Trafficking and Function
Combining vanzacaftor with additional CFTR modulators improves F508del trafficking, cell-surface stability, and ion transport.
- AT1 Blocker and CCR2 Inhibitor Combination for Chronic Kidney Disease
Dual blockade of angiotensin and CCR2 signaling improves renal function and reduces kidney damage markers when monotherapy falls short.
- Biodegradable Polymeric Implants for High-Load Long-Acting Drug Release
Phase inversion creates high-drug-load biodegradable implants that sustain antiretroviral release for months and reduce daily adherence burden.
- Method for preparation of lisdexamfetamine dimesylate dispersible tablet
A direct-compression dispersible tablet balances rapid disintegration with low moisture exposure for stable, palatable lisdexamfetamine delivery.
- Rooibos Extract Composition for Linear Polyphenol Release
A multi-unit Rooibos extract composition combines immediate and sustained release to overcome rapid elimination and maintain polyphenol delivery for hours.
- Orally Disintegrating Tablet Composition for Hardness and Fast Breakdown
A two-stage granulation tablet composition balances high hardness with ultra-fast oral disintegration without freeze-drying.
- Cellulosic-Coated Potassium Chloride for Consistent Sustained Release
Fine potassium chloride crystals coated with up to 9% cellulosic polymer improve sustained release, content uniformity, and manufacturing efficiency.
- Bilayer Sacubitril-Valsartan Tablet for Stable SGLT-2 Coformulation
Physical separation of sacubitril-valsartan and an SGLT-2 inhibitor preserves dissolution, limits impurities, and improves stability.
- Triple Antihypertensive Composition for Blood Pressure Control
A low-dose ARB, diuretic, and calcium channel blocker combination improves blood pressure control while limiting side effects and tolerability issues.