Recombinant Collagen Hydrogel Adhesive for Rapid Seamless Wound Closure
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Solution Overview
Problem
Current wound closure devices, such as sutures and staples, are time-consuming, cause tissue damage, and lack optimal integration, while existing adhesives suffer from weak adhesion, toxicity, or poor biocompatibility, failing to meet the demand for efficient and safe wound healing.
Innovation Solution
A recombinant collagen hydrogel tissue adhesive is prepared using a dual-network structure formed by transglutaminase-mediated enzymatic reactions and Schiff base bonds, incorporating carboxymethyl chitosan, poly-L-lysine, and tetra-arm-polyethylene glycol-aldehyde to achieve strong adhesion, antibacterial properties, and controlled biodegradability, allowing for injectable application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical sutures and staples are used for wound closure, then wound closure can be achieved, but the operation time is time-consuming and tissue damage occurs
Solution Approach 1:
The patent replaces mechanical wound closure systems (sutures and staples) with a chemical/biological adhesive system. The recombinant collagen hydrogel tissue adhesive uses biochemical mechanisms (enzymatic crosslinking, hydrogel formation) to achieve wound closure without mechanical penetration, thereby reducing operation time and avoiding tissue damage from needle punctures.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the adhesive system to optimize performance. By controlling the molecular weight of collagen (50-500 kDa), adjusting crosslinking density, and tuning hydrogel composition, the adhesive achieves rapid setting time while maintaining strong bonding strength, resolving the contradiction between speed and effectiveness.
2Strength
If synthetic organic adhesives like cyanoacrylate glues are used, then adhesive strength is improved, but tissue toxicity occurs
Solution Approach 1:
The patent creates a composite adhesive system combining recombinant collagen (biocompatible, naturally occurring) with crosslinking agents and hydrogel-forming components. This composite approach maintains the adhesive strength needed for wound closure while eliminating the toxicity of pure synthetic adhesives like cyanoacrylate, as collagen is naturally degraded by collagenases without harmful effects.
Solution Approach 2:
The patent employs biodegradable materials that temporarily perform the adhesive function and then naturally decompose. The recombinant collagen hydrogel is designed to be degraded by endogenous collagenases over time, providing temporary but sufficient adhesive strength for wound healing without leaving toxic residues, thus resolving the strength-toxicity contradiction.
3Object-affected harmful factors
If naturally occurring adhesives like fibrin glue are used, then biocompatibility is improved, but adhesive performance in physiological environments deteriorates
Solution Approach 1:
The patent systematically optimizes the molecular parameters of collagen to enhance adhesive performance while maintaining biocompatibility. By controlling collagen molecular weight (50-500 kDa), crosslinking degree, and hydrogel composition, the adhesive achieves bond strengths exceeding 100 kPa in physiological conditions, resolving the weakness of natural adhesives without compromising biocompatibility.
Solution Approach 2:
The patent replaces the weak physical interaction mechanisms of natural adhesives with enhanced biochemical crosslinking mechanisms. The enzymatic crosslinking system (using transglutaminase or collagenase) creates stronger covalent bonds between collagen molecules, significantly enhancing adhesive strength while maintaining the biocompatibility of naturally derived collagen.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive provides rapid wound closure with high adhesion, self-healing, and biocompatibility, replacing sutures and staples, promoting collagen deposition and ensuring secure wound healing with minimal tissue damage.
Implementation Method 1
add transglutaminase to the mixed solution to obtain Solution A
Implementation Method 2
dissolve carboxymethyl chitosan and polylysine in deionized water to obtain a mixed solution
Implementation Method 3
Dissolve recombinant collagen and tetra-arm-polyethylene glycol-aldehyde in deionized water to obtain Solution B
Implementation Method 4
Mix Solution A from Step one and Solution B from Step two evenly to obtain a recombinant collagen hydrogel tissue adhesive
Data Source
AI summary
The invention discloses a preparation method for a recombinant collagen hydrogel tissue adhesive for seamless wound healing. The invention uses recombinant collagen as the main component and utilizes the synergistic effects of various high-molecular polymers to achieve rapid formation of hydrogels with excellent adhesion, antibacterial properties, promotion of collagen deposition at wound sites, and controllable biodegradability. The prepared double-network hydrogel tissue adhesive can be injected into deep wounds, replacing sutures and staples in wound closure applications, with many practical applications.