Multi-Layer Collagen Membrane With Embedded Mesh Against Delamination
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing collagen-based membranes for tissue regeneration suffer from delamination issues, leading to instability and potential infection, especially in areas with substantial tissue movement, due to limitations in thickness, handling properties, and overall size, which affect their clinical efficacy.
Innovation Solution
A multi-layer collagen-based membrane is developed, comprising a bioresorbable mesh embedded between two decellularized natural collagen-based membranes, cross-linked to ensure stability and uniform resorption, without using adhesives, and utilizing methods like UV radiation for cross-linking to enhance peel strength and shape memory.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If a single layer collagen device is used, then the biological benefits of collagen are maintained, but the thickness and overall size are limited and cannot be modified
Solution Approach 1:
The collagen device is divided into multiple layers (first collagen layer, second collagen layer, and intermediate layer) that can be independently manufactured and then assembled. This segmentation allows each layer to be optimized separately while achieving the desired total thickness and customized configuration that cannot be obtained from a single layer.
Solution Approach 2:
The intermediate layer is embedded between the first and second collagen layers, creating a nested multi-layer structure. This nesting approach allows the insertion of functional components (such as reinforcement meshes or additional collagen layers) within the thickness of the device, enabling thickness modification without proportionally increasing the overall device footprint.
2Adaptability or versatility
If collagen devices are derived from natural tissues, then the biological benefits are maintained, but the thickness, handling properties, and overall size are dictated by the target tissue
Solution Approach 1:
By segmenting the device into separate manufacturable layers, the invention enables independent production of each layer with controlled thickness and properties. This allows the first and second collagen layers to be manufactured to specific specifications and then assembled with an intermediate layer, providing customization capability that overcomes the limitations of deriving single-layer devices from natural tissues.
Solution Approach 2:
The device combines multiple collagen layers with an intermediate layer (which may contain reinforcement meshes or other biomaterials) to create a composite structure. This composite approach allows the device to have customized thickness, mechanical properties, and biological characteristics that can be tailored to specific clinical applications, overcoming the inherent limitations of single-source natural tissue derivation.
3Quantity of substance
If multiple collagen sheets are linked together to modify thickness, then the thickness can be increased, but the strength of the lamination must be adequate to withstand delamination
Solution Approach 1:
The intermediate layer serves as a bonding agent between the first and second collagen layers, creating a composite multi-layer structure. This intermediate layer (which may contain reinforcement meshes or other biomaterials) provides mechanical interlocking and chemical bonding that ensures the lamination strength is adequate to withstand delamination forces while maintaining the increased thickness provided by the multiple collagen layers.
4Strength
If adhesives are used to bond collagen layers, then the lamination strength is improved, but the uniform resorption rate is compromised
Solution Approach 1:
The intermediate layer acts as a mediator between the first and second collagen layers, providing bonding without requiring external adhesives. This intermediate layer (which may contain reinforcement meshes or other biomaterials) integrates with both collagen layers through mechanical interlocking and chemical bonding, ensuring lamination strength while maintaining uniform resorption characteristics across all layers since the intermediate layer resorbs at the same rate as the collagen layers.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-layer collagen-based membrane provides enhanced stability and longevity, preventing delamination and tissue damage, while maintaining uniform resorption rates, thus improving clinical outcomes in tissue regeneration procedures.
Implementation Method 1
exposing the membrane assembly to a cross-linking agent such that cross-links form between layers of the membrane assembly
Implementation Method 2
utilizing methods like UV radiation for cross-linking to enhance peel strength and shape memory
Data Source
AI summary
A multi-layer collagen-based membrane that includes a bioresorbable mesh embedded between a first decellularized natural collagen-based membrane and a second decellularized natural collagen-based membrane. The bioresorbable mesh can be formed of a synthetic polymer or demineralized laminar bone. Also provided are two methods for manufacturing a multi-layer collagen-based membrane with or without an embedded bioresorbable mesh.