Pharmaceutical Delivery Mechanism TRIZ Cases

A molded crosslinkable corneal onlay corrects refractive errors without tissue removal, reducing thinning, haze, regression, and recovery time.

Irreversible electroporation with applied pressure forms skin micro-conduits for non-invasive delivery of drugs and vaccines without heat damage.

A low-arginine, pH-controlled anti-IL1R1 antibody formulation enables high protein concentration with lower viscosity and limited aggregation.

An anhydrous block-copolymer bone graft composite preserves osteoinductivity, resists gamma sterilization, and degrades on schedule.

Specific IL2Rγ-binding antibodies block cytokine-induced STAT phosphorylation and help control graft-versus-host disease.

Safranal combined with TOP1 inhibitors helps overcome HCC chemoresistance by blocking DNA repair and increasing apoptosis.

A fibrous porous sponge fixes fluid-absorbing particles in place to improve hemostasis and prevent washout under impaired clotting.

A hydrogel-coated nerve repair membrane self-adheres for stable placement while reducing sutures, tissue trauma, fibrosis, and surgical time.

A fixed-dose sodium and potassium channel blocker combination induces atrial cardioversion while lowering proarrhythmic and hemodynamic risk.

A PTFE-copolymer inner liner cuts catheter friction while improving lateral strength, wear resistance, and durability.

Dual carbodiimide and riboflavin UV-A crosslinking strengthens collagen hydrogel while preserving elasticity, transparency, and tissue integration.

A porous OCP-gelatin composite balances strength and workability, resisting fracture during implantation while retaining shape.

Supercritical CO2 drying preserves open interconnected pores in a biodegradable polymer matrix while maintaining mechanical strength for cell culture.

A self-adhesive hydrogel coating lets a nerve repair membrane stay in place without sutures, reducing trauma, fibrosis, and surgical complexity.

Bispecific aerosolized nanobodies bind viral proteins and mucin to trap airborne viruses on mucosal surfaces before infection.

A hyaluronic acid filler diluted with raw material creates a safety barrier during syringe injection to lower vascular complication risk.

Hydrophilic polymers entrapped in nanoporous biomaterials reduce thrombus formation and improve catheter lubricity without sacrificing strength.

A Garcinia mangostana and fresh Avena sativa blend reduces C. acnes inflammation while preserving skin microbiota balance.

A low-molecular-weight polymer and calcium-phosphorus composite stays stable during injection while conforming to bone defects.

Dual-modified glycosaminoglycan enables injectable hydrogels to covalently bond to fibrocartilage, sealing defects while limiting herniation risk.

Ex vivo cytokine programming creates hybrid Th1/Th17 cells with higher NAD+, lower CD38, and stronger tumor control with persistence.

Core-shell porous calcium particles balance filler volume retention with faster bioactivity and biodegradability through controlled porosity.

EDTA, hydrogen peroxide, glycerol, and ethanol treatment cuts implant tissue calcification while preserving strength and resisting biofilm.

Oral whole coffee fruit extract boosts exosomal BDNF and improves delivery across the blood-brain barrier to raise cerebral levels.

Nigella sativa shifts exercise-related cardiac remodeling toward PI3K-AKT signaling to reduce pathological hypertrophy and support heart function.

Stable peptide-bond linker chemistry and a self-immolative spacer improve ADC storage stability while reducing off-target toxicity.

A UV-cured PVP and poloxamer coating forms durable, lubricious hydrophilic layers on polymer medical devices without plasma treatment.

A single stem-cell differentiation protocol builds cardiac tissue with endothelial and stromal cells to improve engraftment and survival.

An in situ polymerizing polyurethane and acellular tissue matrix fills irregular tissue voids while resisting migration and supporting cell in-growth.

Alternating polymer and soluble-particle layers create a porous biodegradable scaffold that supports cell migration, nutrient diffusion, and tissue repair.

A TiN-coated porous titanium knee implant improves wear resistance and cementless fixation while reducing metal ion exposure and rotation.

Differential scanning calorimetry guides decellularization to lower DNA while preserving matrix structure for cell adhesion and regeneration.

Spray-dried crosslinked glutamic acid polymers thicken aqueous topical formulations, even with salts, while reducing reliance on petrochemical thickeners.

Growth factor monitoring helps validate oral Lactobacillus salivarius treatment for infertility and recurrent pregnancy loss.

ABT-751 crosses the blood-brain barrier to sensitize dividing brain tumor cells to ionizing radiation while limiting damage to surrounding tissue.

Foamed hydration medium with a silicone surfactant hydrates hydrophilic catheters evenly, reducing spillage and excess liquid use.

Hydration medium is injected into a sleeved hydrophilic catheter while distal vents expel air, keeping it lubricious and reducing contamination risk.

Blocking mast cell activation with stabilizers, neuropeptide antagonists, and protease inhibitors helps reduce chronic rosacea inflammation.

Aligned polymer fibers, a spring-patterned inner wall, and conductive hydrogel guide Schwann cells and carry electric cues for nerve regeneration.

A multi-element expression cassette boosts stable C1-INH production to therapeutic levels while supporting long-term gene delivery with low side effects.

An embedded bioresorbable mesh and cross-linking strengthen layered collagen membranes to prevent delamination and preserve uniform resorption.

Direct PD-1 inhibitor injection into skin tumors improves local control while reducing disfiguring surgery, systemic toxicity, and recurrence.

A gapped PLX038 and PARP inhibitor schedule raises tumor SN-38 exposure while limiting dose-limiting toxicities in cancer therapy.

A buffer, non-reducing sugar, and non-ionic surfactant stabilize PVRIG/TIGIT bispecific antibodies at higher temperatures and lower storage cost.

Novel ADC linker-payload structures improve selective cytotoxic delivery to cancer cells, expanding the therapeutic window and growth inhibition.

A nucleic acid and calcium hydroxyapatite filler maintains volume and shape after skin injection while lowering inflammation risk.

A degradable electrospun scaffold and decellularized biomimetic matrix speed endothelialization and recellularization in small-diameter grafts.

Cleavable linker modules on phosphoalkyl polymer drug conjugates improve selective tumor delivery while reducing linker complexity and side effects.

A titanium powder coating on a UHMWPE acetabular cup improves material adhesion, abrasion resistance, and implant durability.

A flexible oral patch uses an absorbent inset to retain liquid and release moisture under pressure for longer dry mouth relief with hygiene benefits.