Porous OCP-Gelatin Bone Regeneration Material for Implant Handleability
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Solution Overview
Problem
Collagen-containing bone regeneration materials are fragile and prone to breaking down during implantation, while gelatin-containing materials exhibit good physical properties but lack handleability.
Innovation Solution
A composite of octacalcium phosphate particles and gelatin with specific particle sizes and molecular weight ranges, forming a porous body with controlled porosity and porosity, enabling the material to maintain its shape and resist fracture during implantation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If collagen-containing bone regeneration material is used, then conformability and workability are improved, but the material becomes fragile and breaks down during implantation
Solution Approach 1:
The patent uses a composite material consisting of hydroxyapatite particles (calcium phosphate compound) and gelatin (polymer material). This composite structure combines the brittleness resistance of hydroxyapatite with the flexibility and workability of gelatin, achieving both ease of operation and adequate strength to prevent breakdown during implantation.
2Strength
If gelatin-containing bone regeneration material is used, then physical strength and formability are improved, but handleability deteriorates
Solution Approach 1:
The patent optimizes specific parameters including the particle size of hydroxyapatite (5-500 μm) and the molecular weight of gelatin (30-70 kDa). These parameter adjustments balance the material's physical strength with its handleability, ensuring the material maintains its shape during implantation while remaining workable.
3Reliability
If calcium phosphate compound is used alone, then bone regeneration performance is improved, but formability and elasticity deteriorate
Solution Approach 1:
The patent creates a composite where hydroxyapatite particles (5-500 μm) provide bone regeneration performance while gelatin (molecular weight 30-70 kDa) provides formability and elasticity. The gelatin acts as a binding matrix that holds the calcium phosphate particles together, enabling the material to be formed into desired shapes while maintaining high bone regeneration capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite exhibits high handleability and shape retention, resisting damage during implantation and maintaining its original shape upon compression, thus improving the practicality of bone regeneration materials.
Implementation Method 1
The porous body is adapted to maintain the shape as formed by compression when in a dry state and expand into the pre-compression state upon absorbing water
Data Source
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AI summary
A bone regeneration material according to the present disclosure includes at least a composite of octacalcium phosphate (OCP) particles and gelatin, and is a porous body having a plurality of pores. The particle size of the octacalcium phosphate particles is 1 µm or more but less than 1 mm, and the molecular weight of the gelatin is in the range of 30 kDa to 70 kDa. Thus, the material is able to resist breaking down during implantation and exhibit high handleability.