Composite Hemostatic Sponge for Particle Retention Under Blood Flow
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Solution Overview
Problem
Existing hemostatic pads, particularly collagen pads, fail to induce hemostasis effectively under conditions of impaired hemostasis, such as after heparinization, and particles used for hemostasis tend to flow away with the bloodstream.
Innovation Solution
A hemostatic sponge is developed with a matrix of fibrous biomaterial containing fluid-absorbing particulate material adhered to it, which enhances hemostasis by local fixation of clotting factors and improves durability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If fluid-absorbing particulate material is used for hemostasis, then hemostatic effectiveness is improved, but particles tend to flow away with the bloodstream
Solution Approach 1:
The patent combines fluid-absorbing particulate material with a fibrous matrix material to create a composite hemostatic sponge. The particles are embedded within the matrix structure, which provides mechanical support and prevents particle washout while maintaining the particles' hemostatic functionality. This merging of discrete particles with a structural matrix resolves the contradiction between particle effectiveness and particle retention.
Solution Approach 2:
The fibrous matrix acts as an intermediary carrier that holds the fluid-absorbing particles in place. The matrix material provides a stable framework that prevents particles from being washed away by blood flow, while still allowing the particles to contact and absorb blood for hemostatic action. This intermediary structure enables both particle retention and hemostatic effectiveness.
2Stability of the object's composition
If particles are incorporated into a fibrous matrix, then particle fixation is improved, but manufacturing complexity increases
Solution Approach 1:
The patent incorporates fluid-absorbing particles into the fibrous matrix during the manufacturing process, before the final product is used. This preliminary incorporation ensures uniform particle distribution and fixation within the matrix structure, eliminating the need for complex post-manufacturing assembly steps and simplifying the overall manufacturing process while achieving stable particle fixation.
Solution Approach 2:
The fibrous matrix is designed with a porous structure that naturally accommodates and holds the particulate material. The porous architecture provides physical spaces for particle embedding while maintaining fluid permeability for blood contact. This porous structure achieves effective particle fixation through its inherent physical geometry rather than requiring complex bonding or assembly processes.
3Duration of action of moving object
If collagen pads are used for wound healing, then wound healing is promoted, but hemostasis is not induced under impaired hemostasis conditions
Solution Approach 1:
The patent creates a composite hemostatic sponge combining collagen fibrous matrix with fluid-absorbing particulate material. The collagen component provides wound healing promotion through its biocompatibility and tissue-regenerative properties, while the added fluid-absorbing particles provide enhanced hemostatic effectiveness even under impaired hemostasis conditions. This composite material integrates the benefits of both components to simultaneously address wound healing and hemostasis challenges.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the collagen pad by incorporating fluid-absorbing particles with specific absorption capacities. This parameter change enhances the material's ability to concentrate clotting factors and induce hemostasis, even in conditions of impaired hemostasis such as heparinization, while preserving the collagen's wound healing properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sponge achieves improved hemostasis by maintaining clotting factors in place, increasing durability, and preventing particle detachment, especially under mechanical tension.
Implementation Method 1
particles of a fluid absorbing particulate material adhered to said matrix material
Implementation Method 2
a matrix of a fibrous biomaterial and particles of a fluid absorbing particulate material adhered to said matrix material
Data Source
AI summary
The present invention provides a hemostatic porous sponge comprising a matrix of a fibrous biomaterial and particles of a fluid absorbing, particulate material adhered to said matrix material, a method of producing these sponges and their use for wound healing.