Mouldable Artificial Bone Composite for Injectable Defect Filling
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing artificial bone materials face issues with fluidity in aqueous environments, leading to washout during injection, and lack of mouldability, making them unsuitable for minimally invasive surgery and inadequate bone defect filling.
Innovation Solution
A mouldable artificial bone composite material composed of degradable polymers with an average molecular weight of 1,000 Da to 20,000 Da, mixed with inorganic calcium-phosphorus compounds, allowing for shaping and injection, maintaining stability in aqueous environments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If artificial bone material uses water-based suspension to achieve fluidity, then it can be injected, but it is easily washed out during injection in aqueous environment
Solution Approach 1:
The patent changes the molecular weight parameter of the polymer from conventional high molecular weight to low molecular weight (1,000-20,000 Da), which fundamentally alters the material's properties. This enables the material to achieve both fluidity for injection and stability in aqueous environments, resolving the contradiction between injectability and environmental stability
Solution Approach 2:
The patent creates a composite material system consisting of low molecular weight polymer and inorganic particles. This composite structure allows the material to exhibit both fluid characteristics for injection and stability in aqueous environments, simultaneously achieving injectability and reliability
2Strength
If artificial bone material uses massive hard solid form, then it provides structural support, but it cannot be freely plasticized and is inconvenient for surgery
Solution Approach 1:
By changing the molecular weight parameter to low range (1,000-20,000 Da), the material transitions from hard solid form to mouldable plasticine state, enabling free shaping while maintaining sufficient structural support capability
Solution Approach 2:
The material exhibits dynamic properties, transitioning from a rigid state to a mouldable state that can be freely shaped and injected, then stabilizing after implantation to provide structural support
3Device complexity
If artificial bone material cannot be freely shaped, then it simplifies the material structure, but it is not easy to fill bone defect sufficiently and leaves gaps
Solution Approach 1:
The low molecular weight parameter (1,000-20,000 Da) enables the material to be freely shaped and molded, allowing complete filling of bone defects without gaps while maintaining relatively simple material composition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composite material provides both mouldability and injectability, ensuring effective bone defect filling and repair, with improved biocompatibility and osteogenic properties.
Implementation Method 1
the artificial bone composite material is in the shape of mouldable plasticine
Implementation Method 2
mixing degradable polymer material and inorganic particles distributed in the polymer material
Implementation Method 3
the degradable polymer material is not easy to dissolve in the aqueous environment and can maintain the stable form of the artificial bone composite material in the aqueous environment
Data Source
AI summary
The disclosure provides a mouldable artificial bone composite material and a preparation method thereof. The mouldable artificial bone composite material is characterized in a composition composed of a degradable polymer material and inorganic particles distributed in the polymer material. The average molecular weight of the polymer material is 1,000 Da to 20,000 Da. The inorganic particles are composed of calcium-phosphorus compounds. The artificial bone composite material has a shape of a mouldable plasticine. The disclosure provides an artificial bone composite material that can be freely shaped and injected, and the disclosure further provides a preparation method of the artificial bone composite material.