Composite Angelica Keiskei and Mulberry Extract for Muscle Strength
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Solution Overview
Problem
Current solutions fail to effectively enhance muscle strength and prevent muscle-related diseases such as sarcopenia, muscular atrophy, and dystrophy, particularly in aging populations.
Innovation Solution
A muscle strength-enhancing composition containing a composite extract of Angelica keiskei and mulberry leaves, mixed at a weight ratio of 1:8 to 16 and extracted with alcohol, which promotes antioxidant activity and muscle function enhancement, thereby suppressing muscle protein breakdown and promoting muscle building.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If exercise and nutrition are provided to maintain muscle mass, then muscle strength is improved, but in aging populations and those with chronic diseases, muscle loss continues due to decreased metabolic capability and exercise capacity
Solution Approach 1:
The patent introduces plant extracts (Angelica keiskei and Morus alba leaves) as intermediary substances that mediate between the body's natural muscle maintenance mechanisms and the pathological processes of muscle loss. These extracts contain bioactive compounds that act as intermediaries to stimulate muscle protein synthesis and inhibit breakdown without requiring increased physical exercise, thereby bridging the gap in muscle maintenance capability for aging and diseased populations.
Solution Approach 2:
The patent changes the biochemical parameters within muscle cells by introducing exogenous plant compounds that alter protein synthesis and degradation pathways. The extracts modify cellular parameters such as activation of mTOR pathway (protein synthesis) and inhibition of ubiquitin-proteasome system (protein breakdown), thereby changing the metabolic state of muscle tissue to favor maintenance and growth even under catabolic conditions.
2Quantity of substance
If protein intake is increased to enhance muscle mass, then muscle building is promoted, but the effectiveness is limited in aging populations due to decreased metabolic capability and anabolic resistance
Solution Approach 1:
The patent combines extracts from two different plant sources (Angelica keiskei and Morus alba leaves) to create a composite formulation that synergistically enhances muscle building efficiency. This composite approach combines different bioactive compounds that work together to overcome anabolic resistance, with Angelica keiskei providing compounds that stimulate protein synthesis and Morus alba leaves contributing antioxidants and anti-inflammatory agents that protect muscle tissue, thereby improving overall muscle building efficiency beyond what single supplements can achieve.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively maintains or strengthens muscles, preventing muscle-related diseases by enhancing muscle strength and promoting muscle regeneration, even in environments where muscle atrophy occurs.
Implementation Method 1
The food composition promotes antioxidant activity (for example, DPPH scavenging activity and ABTS scavenging activity)
Data Source
AI summary
Proposed is a muscle strength-enhancing composition being capable of maintaining or strengthening muscles or preventing muscle-related diseases. More specifically, proposed is a food composition containing a composite extract as an active ingredient obtained by mixing Angelica keiskei and Morus alba L. at a weight ratio of 1:8 to 16 and extracting the resulting mixture with alcohol. The food composition promotes antioxidant activity (for example, DPPH scavenging activity and ABTS scavenging activity) and muscle function enhancement activity which suppresses muscle protein breakdown and promotes muscle building, whereby the food composition prevents muscle-related diseases by enabling muscles to be maintained or strengthened.