Composite SIS-UBM Biomaterial for Tissue Repair
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current biological materials for tissue repair, such as small intestinal submucosa (SIS), face challenges with immunogenicity and mechanical strength, while urinary bladder matrix (UBM) offers high bioactivity and low immunogenicity but is difficult to produce and source control.
Innovation Solution
A composite biological material with a decellularized SIS interlayer sandwiched between decellularized UBM surface layers, enhancing mechanical strength and bioactivity, and using medical adhesives or vacuum pressing for bonding, reduces immunogenicity and production complexity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If SIS is used as biological material for tissue repair, then mechanical strength is improved, but immunogenicity increases
Solution Approach 1:
The patent combines SIS and UBM into a composite material where SIS provides mechanical strength and UBM provides low immunogenicity. The layered structure allows both materials to contribute their respective advantages, creating a composite that outperforms individual materials alone.
Solution Approach 2:
The biological material is divided into distinct layers with SIS forming the interlayer and UBM forming surface layers. This segmentation allows each material to perform its optimal function - SIS for structural support and UBM for bioactivity and low immunogenicity at the tissue interface.
2Reliability
If UBM is used as biological material for tissue repair, then bioactivity and histocompatibility are improved, but mechanical strength and production ease deteriorate
Solution Approach 1:
By creating a composite with UBM surface layers and SIS interlayer, the material achieves both high bioactivity from UBM and sufficient mechanical strength from SIS. The composite structure allows weak but bioactive UBM to be supported by strong SIS.
Solution Approach 2:
UBM is placed specifically at the surface layers where it contacts host tissue, maximizing its bioactivity and low immunogenicity where needed. SIS is placed in the interlayer where mechanical strength is required, creating local optimization of material properties.
3Object-affected harmful factors
If UBM is used as biological material for tissue repair, then immunogenicity is reduced, but production complexity increases
Solution Approach 1:
The material is segmented into UBM surface layers and SIS interlayer, allowing standardized production of each component. SIS can be produced in large quantities with consistent properties, then layered with UBM in a controlled manufacturing process.
Solution Approach 2:
The composite structure serves multiple functions: UBM provides low immunogenicity and high bioactivity at the tissue interface, while SIS provides mechanical strength and structural integrity. This multi-functionality is achieved through a relatively simple layered architecture that can be manufactured efficiently.
Data Source
Figure 1
AI summary
A composite extracellular matrix biomaterial, with a middle layer comprising a decellularized small intestinal submucosa (SIS) (1), and a top layer and a bottom layer comprising a decellularized urinary bladder matrix (UBM) (2). The top and bottom layers completely cover the middle layer, thereby forming a sandwich structure. The sandwich structure allows the UBM (2) to isolate an antigenic property of the SIS (1) and to allowing the UBM to directly contact a host tissue, thereby realizing a high tissue compatibility. The SIS (1) can compensate for a shortcoming of low mechanical strength of the UBM (2). The composite extracellular matrix biomaterial can be used to fill, strengthen, repair, or reconstruct a damage or defect of a fascia, meninges, pleura, pelvic floor, dermis, solid organ, and various types of soft tissues.