Tissue Regeneration TRIZ Cases
- Calcium-Deficient Silicate-Substituted Apatite for High-Temperature Stability
Acid treatment modifies calcium-deficient silicate-substituted apatite to resist phase decomposition above 1100°C while preserving bone repair activity.
- Bioactive Bone Repair Granules with Sustained BMP-2 Release
Calcium phosphate granules embed BMP-2 growth factors to prevent burst release and enhance bone regeneration.
- BMP-2 Peptide Immobilized on Demineralized Bone Matrix
Coating a BMP-2 derived peptide onto a demineralized bone matrix prevents growth factor migration and reduces side effects during bone healing.
- Evanescent Calcium Phosphate Coating for Controlled Antibiotic Release
A bioimplant evanescent coating film releases antibiotics through controlled dissolution of low-crystallinity calcium phosphate.
- Biocompatible Polymer Adjunct for Drug Elution in Surgical Staplers
Composite adjunct material degrades to release medicants, resolving manufacturing difficulties while ensuring reliable tissue healing.
- Octacalcium phosphate gelatin composite bone regeneration
Introducing edge dislocations into octacalcium phosphate within a gelatin matrix improves absorption rates and mechanical strength for large bone defects.
- Decellularized Tissue Sponge Seals Paravalvular Leaks
Low-temperature crosslinking creates a moldable sponge that seals paravalvular leaks without increasing prosthesis complexity.
- Ti-Zr-Cu Alloy for Immediate Dental Implant Placement
A Ti-Zr-Cu alloy with specific heat treatment creates high-strength narrow implants.
- Biomimetic Apatite Precipitation in Polymeric Hydrogel
In situ mineralization of calcium phosphate in PVA hydrogels yields resorbable grafts that mimic natural bone structure.
- Bioactive Porous Bone Grafts with Collagen and Polymeric Reinforcement
Composite bone grafts use segmented porosity and parameter-controlled resorption to maintain mechanical integrity while enhancing vascularization.
- Light Adjustable Intraocular Lens Polymerization Control
Segmented photoinitiators and oxygen quenching prevent residual polymerization, eliminating unintended optical power drift in light adjustable lenses.
- Silver-Coated Porous Titanium Implant for Bone Integration and Infection Control
A silver-coated porous titanium alloy structure promotes osseointegration while inhibiting bacterial adhesion on orthopedic implants.
- rPDGF Bone Graft for Diabetic Periodontal Regeneration
Recombinant PDGF impregnated bone graft material stimulates osteoblast proliferation and angiogenesis to accelerate tissue repair.
- Biological Tissue Decellularization Using Lipopeptide Detergents
Amphiphilic lipopeptides remove cellular components without damaging structural proteins, reducing calcification risk in heart valve prostheses.
- Adjustable Middle Ear Prosthesis with Deformable Stapes Legs
Deformable U-shaped stapes engagement legs adjust length to match patient anatomy, reducing bias loads on the oval window membrane.
- 3D Porous Collagen Scaffolds via High Internal Phase Emulsion
High internal phase emulsions form 3D collagen scaffolds with controlled pore sizes, overcoming electrospinning limitations for tissue engineering.