Evanescent Calcium Phosphate Coating for Controlled Antibiotic Release
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Solution Overview
Problem
Current bioimplants face challenges in controlling the sustained release of antibiotics from hydroxyapatite coatings, leading to unpredictable antibacterial activity and difficulty in preventing postoperative infectious diseases, especially since inorganic antibacterial agents are insoluble and have low elution rates from crystalline hydroxyapatite films.
Innovation Solution
A bioimplant with an evanescent coating film made of calcium phosphate-based materials having crystallinity of 90% or less, which allows for controlled release of antibacterial agents or antibiotics by adjusting the film's evanescence rate and period, enabling the use of insoluble inorganic agents and preventing infectious diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a crystalline hydroxyapatite coating film is used for antibiotic impregnation, then the coating provides good bone adhesion and antibiotic loading capacity, but the uniform pore size and porosity make it difficult to achieve sustained release at a desired rate, causing the medicine to be eluted at a fixed rate
Solution Approach 1:
The patent applies parameter changes by controlling the crystallinity of the hydroxyapatite coating film to be 90% or less. This specific crystallinity parameter enables the coating to maintain good bone adhesion while allowing for controlled evanescence and sustained release of antibiotics at desired rates, resolving the contradiction between adhesion reliability and release duration control
2Ease of operation
If a water-soluble natural organic antibacterial agent is used, then the agent can be eluted from the hydroxyapatite structure, but the antibacterial activity is usually lower than inorganic agents and resistant bacteria are easily generated
Solution Approach 1:
The patent uses parameter changes by controlling the crystallinity parameter of the hydroxyapatite coating to 90% or less. This enables the coating to evaporate and release inorganic antibacterial agents effectively, combining the elution capability of soluble coatings with the high antibacterial activity of insoluble inorganic agents
3Reliability
If an inorganic antibacterial agent is used, then high antibacterial activity is achieved and resistant bacteria are prevented, but the agent is insoluble and it is difficult to utilize elution from a crystalline hydroxyapatite film
Solution Approach 1:
The patent applies parameter changes by setting the crystallinity of the hydroxyapatite coating to 90% or less. This crystallinity parameter allows the coating to maintain structural integrity for bone adhesion while enabling controlled evanescence that releases insoluble inorganic antibacterial agents, achieving both high antibacterial activity and effective elution
4Stability of the object's composition
If the coating film has high crystallinity for structural stability, then the coating maintains its form, but the evanescence rate cannot be controlled and sustained release of medicine is difficult
Solution Approach 1:
The patent applies parameter changes by precisely controlling the crystallinity parameter to be 90% or less. This optimized crystallinity level maintains sufficient structural stability of the coating while enabling controlled evanescence for sustained medicine release, resolving the contradiction between structural stability and release control
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The evanescent coating film provides a controlled release of antibacterial agents, effectively preventing postoperative infections and reducing the risk of artificial joint replacement and amputation by maintaining an optimal antibacterial environment for a predetermined period.
Implementation Method 1
an evanescent coating film made of a calcium phosphate-based material having crystallinity of 90% or less... the evanescent coating film containing an antibacterial agent or an antibiotic... controlled release of antibacterial agents
Data Source
AI summary
To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 90% or less is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film. If necessary, a metal oxide layer made of a metal oxide having an isoelectric point of less than 7 is formed on the bioimplant thereby suppressing adhesion of bacteria.