Compound-Specific Mask for Mass Spectrometry Detector Simplification

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Solution Overview

Problem

Conventional mass spectrometers are complex and costly due to their ability to analyze a wide variety of ions and samples, making them unsuitable for applications that require compound-specific analysis, such as environmental monitoring and security screening.

Innovation Solution

A chemical-compound-specific coding mass spectrometry system that employs a compound-specific mask between the ion source and detector, directing all ion fragments to a single detector element, reducing detector complexity and cost.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional mass spectrometers are designed to analyze a wide variety of ions and samples, then versatility and generality are improved, but device complexity and cost increase

Engineering Contradiction:
ImproveversatilityVSAvoidcomplexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent extracts only the specific ion fragments of interest from the full mass spectrum by using a compound-specific mask that selectively transmits only those fragments. This eliminates the need for complex detector arrays required in conventional systems, thereby reducing device complexity while maintaining compound-specific detection capability

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The compound-specific mask serves multiple functions: it acts as a spatial filter for ion fragments, a compound identifier, and a signal concentrator. By making the mask compound-specific rather than application-specific, the system achieves versatility for different compounds while maintaining a simple detector structure

Inventive Principle:
Principle #6Universality (Multi-functionality)

2Measurement precision

If conventional mass spectrometers use multiple detector elements to detect ion fragments, then measurement precision is improved, but device complexity and cost increase

Engineering Contradiction:
Improvedetection precisionVSAvoiddetector complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent merges the detection function for multiple ion fragments onto a single detector element by using the compound-specific mask to spatially concentrate all relevant fragments onto one detection point. This maintains measurement precision through selective detection while dramatically reducing detector complexity

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The compound-specific mask acts as an intermediary between the ion source and detector, performing the function of selecting and concentrating ion fragments before they reach the detector. This intermediary element enables a single detector to achieve what would otherwise require multiple detectors, reducing system complexity

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach results in a less complex and more cost-effective mass spectrometer design, specifically suited for applications like environmental monitoring and security screening, with improved compound specificity and reduced confusion from similar compounds.

Implementation Method 1

a mass analyzer that separates the produced ion fragments according to their mass

Methodology Applied
Scientific EffectMass-to-charge ratio separation:

Implementation Method 2

a compound-specific mask interposed between the ion source and the detector that substantially all directs the compound-identifying ion fragments to a single detector element

Methodology Applied
Scientific EffectSpatial filtering and ion beam manipulation:

Data Source

PatentUS10410850B2Systems, methods, and structures for compound-specific coding mass spectrometry
Publication Date: 2019.09.10 DUKE UNIV
  • US10410850B2 patent drawing
  • US10410850B2 patent drawing
  • US10410850B2 patent drawing

AI summary

Aspects of the present disclosure describe systems, methods, and structures for compound-specific coding mass spectrometry wherein compound-specific masks/codes are positioned between an ion source and detector of a mass spectrometer.