Corona Discharge Ion Transfer Layout for Higher MS Sensitivity
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Solution Overview
Problem
The related art ionization method results in diffusion of ionized substances into open spaces, leading to reduced analytical sensitivity.
Innovation Solution
An ionization device with a corona discharge section partitioned by an electrode and a transfer section, where the ionized analyte is transferred directly to a mass spectrometry apparatus without diffusing into open spaces, using a configuration that includes an opening in the discharge electrode and a through hole in an insulation plate to facilitate direct transfer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If a corona discharge is performed in the open space of the ion source cell, then the ionization process can be simplified, but the ionized substance is diffused into the open space and analytical sensitivity is lowered
Solution Approach 1:
The ion source cell is divided into two separate sections by a partition wall: an ionization chamber where corona discharge occurs and an introduction chamber where ions are collected. This segmentation prevents diffusion of ionized substances into open space while maintaining a straightforward ionization process, thereby resolving the contradiction between device simplicity and measurement precision.
Solution Approach 2:
A partition wall with a specific opening structure acts as an intermediary between the ionization chamber and introduction chamber. This intermediary structure allows controlled transfer of ionized substances from the ionization region to the introduction region, preventing unwanted diffusion while enabling efficient ion transfer, thus improving analytical sensitivity without complicating the ionization process.
2Measurement precision
If the ionized substance is transferred directly to the mass spectrometry apparatus, then analytical sensitivity is improved, but the device structure becomes more complex
Solution Approach 1:
The partition wall serves multiple functions simultaneously: it separates the ionization chamber from the introduction chamber, provides structural support, and contains the opening that enables controlled ion transfer. This multi-functionality reduces the need for additional separate components, thereby achieving direct ion transfer for improved sensitivity without proportionally increasing device complexity.
Solution Approach 2:
The partition wall is designed as a thin structure with a precisely positioned opening, allowing efficient ion transfer while minimizing material usage and structural complexity. This thin-film approach enables direct transfer of ionized substances to the mass spectrometry apparatus with minimal additional structural complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves analytical sensitivity by ensuring the ionized substances are efficiently transferred to the mass spectrometry apparatus, reducing diffusion and maintaining high detection intensity.
Implementation Method 1
an ion formation section configured to ionize an analyte via a corona discharge
Data Source
AI summary
An ionization device includes an ion formation section configured to ionize an analyte via a corona discharge; and a transfer section configured to transfer the ionized analyte to a mass spectrometry apparatus. The ion formation section and the transfer section are partitioned by one electrode of a pair of electrodes that generate the corona discharge. The one electrode has an opening.