Samples Introduction/Extraction TRIZ Cases

Desalting, acoustic ejection, and ion mobility selection cut LC/MS run time and ion suppression for small-volume urine analysis.

A slotted ion funnel separates ion flow from gas exhaust to cut turbulence and fragmentation while enabling real-time calibrant introduction.

A cooled gas-heater fixture blocks heat conduction to the sample probe, preventing boiling and stabilizing ion analyzer signals.

Initial peak-width scans automatically set dwell times in differential mobility mass spectrometry, cutting cycle time while preserving multi-analyte precision.

Low-power laser feedback and radiant heating track surface protein denaturation in real time for uniform, reproducible MALDI-MS sample prep.

Mass spectrometry detects mycobacterial lipid peak sets in transplant candidate samples, enabling faster screening than culture-based methods.

Profiled ion funnel entrances and exits limit gas conductance at higher pressure while preserving ion trajectories and fragmentation efficiency.

A PTFE membrane transfer line swaps atmospheric gas for sweep gas, keeping ICP plasma stable during laser ablation sample changeover.

Low-pressure ion guidance aligns analyte flow with reagent ions to boost sensitivity, cut memory effects, and speed sequential sample screening.

A non-sealed inert-gas chamber enables non-contact laser ablation ICP-MS, limiting contamination and aerosol diffusion for fast local trace analysis.

Neutral droplet spray generates analyte ions at ambient pressure without sample preparation, vacuum, high voltage, or close instrument placement.

Hydrophobic boundaries confine inspection liquid on semiconductor surfaces, enabling faster collection and cleaner metal contamination analysis.

Focused tonebursts raise and sustain a liquid mound, then eject subwavelength droplets in sequence to improve sample throughput and reduce waste.

Segmented reaction and separation with rinsing flows keeps IRMS interface channels clear during extended analysis of particle-forming samples.

A hermetically sealed chamber with inert gas flow and climate control stabilizes vapor analysis and reduces contamination between samples.

Atmospheric bubbles segment transport liquid in an open port interface, improving sample isolation, peak resolution, and mass spectrometry throughput.

Sequential ion fraction transfer preserves narrow isolation quality across a wider precursor m/z range while improving duty cycle in mass spectrometry.

An angled gas injection creates a counter-flow vortex that rejects large droplets, improving ICP aerosol transport and plasma stability.

A rough-top, smooth-bottom porous support retains sample components while draining excess liquid to improve DESI mass spectrometry sensitivity.

Pressure-driven surface impact breaks aerosol molecular clusters into gaseous ions, improving sensitivity while reducing interface contamination.

High-flow flushing with a closable open port clears bubbles and contamination, speeding MS sample transfer through long conduits.

Recirculating gas from downstream to upstream sustains high ion-separation flow while reducing vacuum pump demand and improving throughput.

A dual-porosity substrate keeps samples in the measurement region while blocking foreign matter, improving ionization accuracy and handling.

A transparent substrate extends post-desorption ionization while shielding optics from ablation debris, improving mass spectrometry sensitivity.

Independent control of ionization and pressure-adjustment gas keeps ion source pressure stable despite atmospheric changes, preserving sensitivity.

Organic-acid contact plus heating improves cytoplasmic extraction and peak intensity for identifying strong-walled microorganisms by mass spectrometry.

Negative EAD fragments cooled deprotonated peptide ions while preserving fragile moieties for accurate structural reconstruction.

Direct low-flow standard solution addition lets LA-ICP-MS quantify sample-gas elements without solid references while correcting sensitivity shifts.

A dual-outlet purge chamber removes atmospheric gas between samples while maintaining cell pressure and preventing ICP torch plasma extinguishment.

Pulsed inductive charging synchronizes nanoelectrospray droplets with interface opening to cut flow rates and boost mass spectrometry sensitivity.

Overlapping acoustic ejection mass spectrometry peaks are deconvolved with fitted peak profiles to preserve integration accuracy at high throughput.

Laser ablation ICP-MS pinpoints minute foreign matter on coated semiconductor substrates to control contamination in chemicals and resist compositions.

Multiple nozzle apertures form a heated gas curtain aligned with the capillary, improving sample volatilization and mass spectrometry accuracy.

Focused tonebursts raise a liquid mound and sequentially eject subwavelength droplets for precise transfer with low sample waste and less cross-contamination.

A dual-mode heater and corona discharge setup pre-cleans the capillary tip to limit contaminant buildup and keep atmospheric solids analysis accurate.

Axial actuator motion automatically rotates the tool head to couple or uncouple vacuum modules with less user manipulation and lower damage risk.

Iterative outlier removal refines ICP-MS signal baselines and thresholds, separating nanoparticle events from background interference.

A heat transfer member in the assist gas passage raises gas temperature efficiently, improving liquid-sample desolvation without costly heaters.

A partitioned corona discharge path transfers ionized analyte directly into the mass spectrometer to limit diffusion and improve sensitivity.

Unique ADE ejection patterns mark the first sample and align delayed mass peaks with stored ejection times for accurate AEMS data.

Partition grooves on a porous sample support confine liquid to separate measurement regions, preventing spread and improving mass spectrometry accuracy.

Electromagnetic waves pass through a transparent substrate to post-ionize desorbed molecules, boosting sensitivity while limiting optical contamination.

Internal standard addition and dynamic dilution improve online MS quantitation across changing reaction concentrations while reducing carryover.

Fluid pressure monitoring positions an open port interface at the sample surface, avoiding cameras or lasers while enabling accurate sample collection.

By converting Br and I in geological samples into noble gases, this case avoids hazardous pretreatment and improves trace halogen accuracy.

Alternating planar electrodes and laminar gas flow reduce space charge, letting the analyzer handle higher ion currents without losing sensitivity.

Independent time-of-flight and intensity capture for each laser shot improves MALDI-TOF reproducibility despite sample variation.

Automatic vacuum pump throughput control stabilizes interface pressure in ICP-MS, improving ion transfer and detection sensitivity.

An air-tight chamber enables solvent-free mass spectrometry of air-sensitive materials without transfer decomposition or structural change.

Electromagnetic heating rapidly evaporates samples in a vacuum for mass spectrometry, cutting detection time for high-throughput chemical screening.

Abnormal signal checks trigger automatic sample re-runs, ejection adjustment, and recalibration to preserve acoustic MS throughput.

Calibrant ion mass is used to determine droplet volume across fluid levels, reducing repeated dispenser calibration in MS workflows.

A bifurcated inert gas line keeps the reagent refrigerator clean during vessel replacement by limiting outside air, oxygen, and condensation.

A matched shielding and torch aperture helps maximize sample ion generation while maintaining microwave shielding across analyzers.

Focused tonebursts eject subwavelength droplets with controlled trajectory, cutting sample waste and cross-contamination in analytical loading.

Combining nano-electrospray with UV photoionization boosts sensitivity for low-polar trace compounds in tiny samples while reducing matrix interference.

Controlled preheating of ICP sample gas cuts diffusion losses and improves ionization sensitivity at lower plasma power.

Combines rapid mass screening with isotopic MRM quantification in one sample prep step to avoid dilution, reanalysis, and detector saturation.

Multiple heated inlets inject ions orthogonally into an ion funnel to raise total ion current while limiting crosstalk and transmission losses.

Pressure tuning in a quadrupole mass spectrometer suppresses ionization of near-mass interferents for more accurate gas quantification.

A capture liquid separates sample droplets from immiscible segmenting liquid, reducing contamination while controlling dispersion and dilution.

Mid-infrared laser ablation preserves nanoparticle tags for sharp ICP-MS spike detection and accurate counting in solid samples.

Dynamic mass filtering correlates electrophoretic mobility with m/z ratios to eliminate unwanted charge state interference.

Axial introduction via the ion passageway avoids RF field deflection, maintaining particle energy for efficient fragmentation.

A PESI ion source solvent supply unit maintains a controlled reservoir above the sample to ensure consistent probe ionization.