Porous Sample Support Body With Partition Grooves for Region Isolation

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Solution Overview

Problem

In existing sample targets with porous alumina layers, liquid samples can spread from one region to another during ionization, leading to incomplete analysis and contamination between measurement regions.

Innovation Solution

A sample support body with a substrate and a porous layer featuring partition grooves that separate regions, where the grooves are wider than they are deep, preventing sample spread and allowing for efficient ionization and mass spectrometry.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a porous alumina layer is used for sample ionization, then ionization efficiency is improved, but sample spread between regions occurs

Engineering Contradiction:
Improveionization efficiencyVSAvoidsample spread
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The front surface of the porous layer is divided into multiple independent measurement regions by forming partition grooves. These grooves physically separate the regions, preventing liquid samples from spreading between them while maintaining the ionization functionality of the porous alumina material in each region.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Different regions on the front surface are given distinct functions through partitioning. Each measurement region can be optimized for specific ionization tasks, and the partition grooves create local boundaries that control sample flow patterns, ensuring samples remain confined to their designated regions.

Inventive Principle:
Principle #3Local quality

2Productivity

If multiple measurement regions are created for simultaneous analysis, then productivity is improved, but sample contamination between regions increases

Engineering Contradiction:
Improveanalysis throughputVSAvoidregion isolation
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The front surface is segmented into multiple measurement regions that can simultaneously accommodate different liquid samples. The partition grooves ensure complete isolation between regions, allowing parallel analysis of multiple samples without cross-contamination, thereby increasing productivity while maintaining precision.

Inventive Principle:
Principle #1Segmentation

3Manufacturing precision

If partition grooves are formed to prevent sample spread, then region isolation is improved, but device complexity increases

Engineering Contradiction:
Improveregion isolationVSAvoidstructure complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The partition grooves are formed within the porous alumina layer, utilizing the material's inherent porous structure. This approach integrates the partitioning function into the existing porous layer without requiring additional complex structures, maintaining simplicity while achieving effective region isolation.

Inventive Principle:
Principle #31Porous materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The partitioned sample support body effectively contains and ionizes samples within defined regions, preventing cross-contamination and enabling accurate mass spectrometry analysis.

Implementation Method 1

a porous layer provided on the substrate and having a front surface on a side opposite to the substrate; the porous layer includes a main body layer having a plurality of holes opening to the front surface

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Implementation Method 2

a component of the sample is ionized by irradiating the layer of porous alumina on which the sample is disposed with laser light

Methodology Applied
Scientific EffectLaser ablation/ionization: Laser Ablation

Data Source

PatentUS12469689B2Sample support body, ionization method, and mass spectrometry method
Publication Date: 2025.11.11 HAMAMATSU PHOTONICS KK
  • US12469689B2 patent drawing
  • US12469689B2 patent drawing
  • US12469689B2 patent drawing

AI summary

A sample support body is used for ionizing a component of a sample. The sample support body includes: a substrate; a porous layer provided on the substrate and having a front surface on a side opposite to the substrate; and a partition portion partitioning the front surface into a first region and a second region. The porous layer includes a main body layer having a plurality of holes opening to the front surface. The partition portion includes a partition groove formed on the front surface so as to pass between the first region and the second region.