Creatinine Calibration Solution Temperature Model
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Solution Overview
Problem
Existing methods for calibrating creatinine measuring devices have a short usage period, typically less than 14 days, due to temperature-dependent equilibrium shifts in creatinine and creatine solutions, requiring frequent replacement and precise temperature control, which is inconvenient and costly.
Innovation Solution
A method using a temperature model to estimate the temperature profile experienced by calibration solutions over time, allowing for accurate calibration of creatinine measuring devices even when the exact temperature history is unknown, eliminating the need for continuous temperature recording and enabling longer solution storage and usage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If calibration solutions are stored for extended periods, then replacement frequency decreases and operational convenience improves, but temperature-dependent equilibrium shifts cause concentration inaccuracies
Solution Approach 1:
The patent changes the chemical parameters of the calibration solution by adding creatine and creatinine in specific non-equilibrium ratios, along with buffer substances and stabilizers. This creates a solution that maintains stable concentrations over extended periods without requiring strict temperature control, resolving the contradiction between long storage duration and measurement accuracy.
Solution Approach 2:
Instead of using expensive, long-lived calibration solutions requiring precise temperature control, the patent employs a disposable calibration solution with extended stability. The solution can be stored at room temperature for prolonged periods without significant concentration changes, eliminating the need for refrigeration and frequent replacement while maintaining accuracy.
2Measurement precision
If temperature control is implemented to maintain concentration stability, then measurement accuracy improves, but device complexity and operational cost increase
Solution Approach 1:
The patent extracts the temperature control requirement from the calibration solution system. By formulating a solution with creatine, creatinine, buffer substances, and stabilizers in specific ratios, the solution becomes inherently stable without requiring external temperature control mechanisms, thereby reducing device complexity while maintaining accuracy.
Solution Approach 2:
The calibration solution is designed to self-regulate its stability through its chemical composition. The buffer substances and stabilizers automatically maintain pH and concentration equilibrium without external intervention, allowing the solution to resist temperature-induced changes without requiring active temperature control systems.
3Measurement precision
If frequent replacement of calibration solutions is required, then concentration accuracy is maintained, but productivity and operational efficiency decrease
Solution Approach 1:
The patent prepares calibration solutions with predetermined compositions of creatine, creatinine, buffer substances, and stabilizers that are designed to remain stable over extended periods. This preliminary formulation ensures that the solutions maintain accurate concentrations throughout their extended shelf life, eliminating the need for frequent replacement and improving operational efficiency.
4Measurement precision
If precise temperature monitoring is implemented, then concentration calculations improve, but device complexity and operational burden increase
Solution Approach 1:
The patent removes the requirement for temperature monitoring from the calibration process. By using a solution formulation with creatine, creatinine, buffer substances, and stabilizers that maintains stable concentrations independent of temperature fluctuations, the system eliminates the need for temperature sensors, data logging, and complex calculations, thereby simplifying operation while maintaining accuracy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach extends the calibration solution's usability beyond 14 days, reducing the need for frequent replacements and minimizing errors by accurately calculating creatinine and creatine concentrations based on temperature models, even with unknown temperature profiles.
Implementation Method 1
changes to the temperature of the solution will shift the equilibrium ratio, and therefore the cCr and cCrn will change
Implementation Method 2
Crn can be converted into Cr and vice versa by water hydrolysis and elimination respectively
Implementation Method 3
After a sufficient period of time at a constant temperature the mixture will reach a dynamic equilibrium in which cCr and cCrn are constant
Implementation Method 4
The CA facilitates equilibration. Once equilibrium is reached at a given temperature, the cCr and cCrn can be determined
Data Source
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AI summary
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.