Crosslinkable Embolic Compositions for Complete In Situ Occlusion
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Solution Overview
Problem
Existing crosslinkable compositions struggle with delivering and forming crosslinked materials in situ, particularly in closed cavities and difficult-to-access body sites, and lack efficient methods for filling space or space filled with blood, such as in vascular applications.
Innovation Solution
A kit comprising a first fluid composition with a polysiloxane and silica filler, and a second fluid composition with a hydride material, along with a catalyst for crosslinking, which when mixed, form a crosslinkable composition that can be injected and crosslink in situ, using a delivery system like a catheter.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a crosslinkable composition is delivered to closed cavities or difficult-to-access body sites, then the ability to fill space and provide complete occlusion is improved, but the complexity of delivering and forming the crosslinked material in situ increases
Solution Approach 1:
The composition is divided into two separate injectable components: a first composition containing a polysiloxane with unsaturated groups and a second composition containing a polysiloxane with hydride groups. These components are delivered separately through catheters to the target site, where they mix and crosslink to form the occlusive material. This segmentation allows simpler delivery of individual components while achieving complete occlusion through their reaction products.
Solution Approach 2:
A catalyst is introduced as an intermediary substance that facilitates the crosslinking reaction between the unsaturated and hydride groups. The catalyst enables the two separate compositions to react and form the crosslinked network structure in situ, simplifying the delivery process while ensuring reliable complete occlusion at the target site.
2Reliability
If in-situ crosslinking is used to deliver compositions to closed cavities, then the ability to fill space and support surrounding structures is improved, but the time required for the crosslinking process increases
Solution Approach 1:
The crosslinking process is replaced from a purely time-dependent chemical reaction with a catalyst-based system. The catalyst introduces a chemical mechanism that accelerates the crosslinking reaction, reducing the time required for the composition to transition from injectable fluid to crosslinked solid while maintaining the space-filling capability and structural support functions.
3Productivity
If a catalyst is added to the fluid compositions, then the crosslinking reaction speed is improved, but the biocompatibility and safety profile worsen
Solution Approach 1:
The catalyst is designed to be locally active, meaning it is introduced in small quantities and functions only at the target site where the crosslinking reaction is needed. The catalyst's activity is confined to the local environment of the injection site, minimizing systemic exposure and maintaining overall biocompatibility while achieving fast crosslinking reaction speed at the required location.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crosslinkable composition effectively occludes targeted vasculature, providing complete fill and occlusion with controlled distal penetration and visibility during procedures, demonstrating biocompatibility and efficacy in vascular embolization.
Implementation Method 1
at least one of said first and second fluid compositions comprises a catalyst for catalyzing a reaction between the unsaturated groups and the hydride groups
Implementation Method 2
the first fluid composition and the second fluid composition, when mixed, form a crosslinkable composition
Data Source
AI summary
The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.