Crosslinkable Embolic Composition for In Situ Vascular Filling

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Solution Overview

Problem

Existing crosslinkable compositions face challenges in delivering and forming crosslinked materials effectively in closed cavities and difficult-to-access body sites, such as the vascular system, without causing complications.

Innovation Solution

A biocompatible crosslinkable composition kit comprising polysiloxane and hydride materials with unsaturated and hydride groups, silica fillers, and imaging agents, along with catalysts, is used to form crosslinkable compositions in situ, which can be injected and crosslink within the body.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If crosslinkable compositions are delivered intravascularly to closed cavities and difficult-to-access body sites, then the ability to fill space and support tissues is improved, but the risk of causing complications and harm to surrounding tissues increases

Engineering Contradiction:

Improveability to deliver to closed cavities and difficult-to-access body sitesVSAvoidcomplications and harm to surrounding tissues

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The composition utilizes controlled crosslinking parameters (temperature, catalyst activation, mixing ratio) to achieve gradual gelation and crosslinking in situ. This controlled parameter change allows the material to fill complex vascular structures and closed cavities while minimizing harm to surrounding tissues through gradual rather than abrupt transformation.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention employs composite materials comprising polysiloxane backbone, crosslinking agents, silica particles, and imaging agents combined in a specific formulation. This composite structure provides both the desired adaptability for delivering to difficult-to-access sites and the biocompatibility needed to minimize harm, with each component contributing specific properties that balance effectiveness and safety.

Inventive Principle:

Principle #40Composite materials

2Reliability

If in-situ-forming crosslinked compositions are used to fill empty space and support tissues, then tissue support and embolization effectiveness are improved, but the complexity of delivering and forming the crosslinked material increases

Engineering Contradiction:

Improvetissue support and embolization effectivenessVSAvoidcomplexity of delivering and forming crosslinked material

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The delivery system is segmented into separate components (polysiloxane composition, crosslinking agents, catalysts) that are mixed in situ at the target site. This segmentation simplifies the delivery process by allowing each component to be delivered separately through standard catheters, while the crosslinking reaction occurs automatically upon mixing, reducing the need for complex delivery devices.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The composition is designed to be self-crosslinking upon contact with body fluids or through automatic catalyst activation. This self-service mechanism eliminates the need for external energy sources, complex heating systems, or sophisticated control mechanisms, thereby reducing device complexity while maintaining reliable tissue support and embolization effectiveness.

Inventive Principle:

Principle #25Self-service

3Productivity

If crosslinking reaction is accelerated to improve filling speed, then productivity is improved, but the control over crosslinking timing and location becomes more difficult

Engineering Contradiction:

Improvefilling speedVSAvoidcontrol over crosslinking timing and location

Core Design Contradiction:

ProductivityVSManufacturing precision

Solution Approach 1:

Catalysts are used as intermediaries to control the crosslinking reaction timing and location. The catalysts remain dormant until activated by specific conditions (temperature, pH, contact with body fluids), allowing the filling process to proceed at controlled speed while maintaining precision over when and where crosslinking occurs. This intermediary mechanism decouples the filling speed from the crosslinking rate.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The polysiloxane composition is prepared in advance with crosslinking agents and catalysts in a stable, non-reactive state. This preliminary preparation allows the material to be stored and transported without premature crosslinking, while ensuring that crosslinking occurs rapidly and controllably once delivered to the target site and activated by body conditions, thus achieving both high productivity and precise timing control.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions effectively fill and support tissues, providing embolization and tissue support in the vascular system, with controlled crosslinking and minimal invasiveness.

Implementation Method 1

at least one of said first and second fluid compositions comprises a catalyst for catalyzing a reaction between the unsaturated groups and the hydride groups

Methodology Applied

Scientific EffectCatalysis: Catalysis

Data Source

PatentUS12478710B2Embolic compositions and methods

Publication Date: 2025.11.25 ARSENAL MEDICAL INC

AI summary

The present disclosure pertains to crosslinkable compositions and systems as well as methods for forming crosslinked compositions in situ, including the use of the same for embolizing vasculature including the neurovasculature within a patient, among many other uses.