Blood Analysis Using CRP and Particle Volume for Malaria Detection
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Solution Overview
Problem
Conventional blood analysis devices for malaria determination require a highly functional and expensive constitution, making them unsuitable for widespread use in areas where daily malaria testing is necessary.
Innovation Solution
A blood analysis device and computer program that utilize CRP values and volume frequency distribution of particles, combined with machine learning models, to determine malaria positivity using less expensive components and configurations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional blood analysis devices are used for malaria determination, then measurement precision is improved, but device complexity and cost increase
Solution Approach 1:
The patent extracts and emphasizes only the most critical measurement parameters (volume frequency distribution and CRP value) from the complete blood analysis, eliminating the need for complex multi-parameter analysis while maintaining malaria determination accuracy
Solution Approach 2:
The patent makes existing blood analysis devices perform multiple functions by adding malaria determination capability using their existing particle measurement and CRP measurement capabilities, rather than requiring dedicated malaria testing equipment
2Measurement precision
If conventional blood analysis devices are used for malaria determination, then measurement precision is improved, but manufacturing cost increases
Solution Approach 1:
The patent employs disposable reagents and consumables (hemolytic agents, diluents, test strips) that are inexpensive to manufacture and replace, significantly reducing the overall device cost while maintaining measurement precision through standardized test protocols
3Reliability
If CRP value and volume frequency distribution are used together, then reliability is improved, but device complexity increases
Solution Approach 1:
The patent combines CRP value measurement and volume frequency distribution analysis into a single integrated determination system, where both parameters are measured using existing device components and evaluated together to improve reliability without requiring separate complex measurement systems
Data Source
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AI summary
A determining part is provided in an analysis part of a blood analysis device. The determining part determines that the aforementioned blood specimen has high likelihood of malaria positivity when a frequency peak part exists in a volume range unique to malaria plasmodium in volume frequency distribution based on the aforementioned volume measured value, or when a CRP value based on the aforementioned CRP parameter value is not less than the threshold value determined in advance.