Cyclopropylamide Compounds for Resistant Sea Lice Treatment in Fish
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing treatments for sea lice infestations in fish are ineffective against resistant populations and lack long-lasting efficacy, causing significant economic losses and animal welfare issues in fish farming.
Innovation Solution
The use of aliphatic cyclopropyl amide compounds, including their derivatives and veterinary acceptable forms, for treating and preventing sea lice infestations through oral, topical, or bath treatments, which effectively target juvenile and adult sea lice stages without harming fish or other marine organisms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments (organophosphates, pyrethroids, avermectins) are used to control sea lice, then sea lice infestations are treated, but resistance develops and efficacy is reduced
Solution Approach 1:
The patent applies parameter changes by introducing a novel chemical structure class (cyclopropyl amide compounds with specific molecular formulas) that differs fundamentally from existing treatment classes. This structural parameter change creates compounds with new mechanisms of action that are effective against sea lice populations resistant to conventional treatments, thereby resolving the efficacy-resistance contradiction.
2Reliability
If existing treatments are applied to control sea lice, then parasite infestation is reduced, but duration of action is insufficient
Solution Approach 1:
The patent employs partial or excessive action by designing cyclopropyl amide compounds that, when administered at appropriate doses, provide prolonged protection beyond the typical treatment duration of existing products. The compounds maintain effective concentrations in the fish system for extended periods, ensuring sustained parasite control without requiring frequent reapplication.
3Reliability
If new cyclopropyl amide compounds are used to control sea lice, then efficacy against resistant strains is improved, but potential toxicity to fish and marine organisms must be evaluated
Solution Approach 1:
The patent applies preliminary action by conducting comprehensive safety evaluations and toxicity assessments of cyclopropyl amide compounds before their deployment against resistant sea lice populations. This advance testing ensures that the compounds achieve the necessary therapeutic efficacy while maintaining an acceptable safety margin for fish and marine organisms, resolving the contradiction between effectiveness and potential harm.
Data Source
Figure 1
Figure 1
Figure 1
AI summary
The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the following formula (Formula (I))