Daikenchuto Dosage Prediction via Intestinal Flora Bacteroidetes Firmicutes Ratio
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current Kampo medical treatments for conditions like hypertension lack objective indices to predict the effectiveness of Daikenchuto and determine appropriate dosages, relying heavily on medical doctor consultation techniques and subjective assessments.
Innovation Solution
A method involving the analysis of intestinal flora to determine the ratios of specific enteric bacteria (Bacteroidetes to Firmicutes and Bacteroidetes to Clostridium) to predict Daikenchuto's effectiveness and adjust dosages, using a kit with reference materials to guide treatment decisions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Kampo medical care uses subjective consultation techniques to select treatments, then treatment personalization is achieved, but objective prediction of effectiveness is lost
Solution Approach 1:
The patent replaces the mechanical/subjective consultation technique with a biochemical/objective measurement system. By using biochemical tests to detect intestinal flora composition (Bacteroidetes/Firmicutes ratio) as an objective index, the system substitutes the doctor's subjective assessment with measurable biological data, enabling precise prediction of Daikenchuto effectiveness without requiring complex diagnostic procedures.
2Reliability
If the same drug is selected for all patients with the same disease, then treatment simplicity is maintained, but individual effectiveness is reduced
Solution Approach 1:
The patent applies parameter changes by using the Bacteroidetes/Firmicutes ratio as a biomarker to stratify patients into different treatment groups. Instead of treating all patients uniformly, the system adjusts treatment selection based on this measurable parameter, thereby improving reliability of treatment effectiveness while maintaining operational simplicity through clear diagnostic criteria.
3Productivity
If Daikenchuto is prescribed without objective criteria, then treatment accessibility is improved, but unnecessary treatments increase patient burden
Solution Approach 1:
The patent implements feedback by using objective biochemical measurements (intestinal flora analysis) to predict treatment response before administration. This feedback mechanism allows clinicians to identify patients who are likely to respond positively to Daikenchuto, thereby improving treatment efficiency and reducing patient burden by avoiding unnecessary treatments in non-responders.
Data Source
AI summary
Provided are a method for predicting the effect of Daikenchuto, a method for determining the dosage of Daikenchuto, etc. using an objective index by a method for predicting the effectiveness of Daikenchuto in a patient characterized by including the following steps (a) and (b): (a) a step of determining the ratio of the phylum Bacteroidetes to the phylum Firmicutes (Bm/Fm ratio) in the intestine of the patient by analyzing the intestinal flora of the patient; and (b) a step of determining the effectiveness of Daikenchuto in the patient by comparison with criteria such that when the Bm/Fm ratio is lower than a reference value, Daikenchuto is more effective, and when the Bm/Fm ratio is higher than a reference value, Daikenchuto is less effective, and a method for determining the dosage of Daikenchuto for a patient characterized by including the following steps (a) and (e): (a) a step of determining the ratio of the phylum Bacteroidetes to the phylum Firmicutes (Bm/Fm ratio) in the intestine of the patient by analyzing the intestinal flora of the patient, and (e) a step of determining the dosage of Daikenchuto for the patient by decreasing the dosage of Daikenchuto for the patient when the Bm/Fm ratio determined in the step (a) is a lower value than a reference value, and increasing the dosage of Daikenchuto for the patient when the Bm/Fm ratio is a higher value than a reference value.