1,4-Diaminobutane Purification via pH Adjustment and Distillation
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Solution Overview
Problem
Current methods for producing 1,4-diaminobutane through fermentation result in low concentration and require toxic compounds or expensive catalysts, and there is a need for an effective purification method to obtain high-purity 1,4-diaminobutane from fermentation solutions.
Innovation Solution
A method involving concentration of the fermentation solution, adjustment of pH to 12 or higher with a base, and subsequent distillation to recover high-purity 1,4-diaminobutane, which includes removing solvent and optionally bacterial cells to enhance purification and yield.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If 1,4-diaminobutane is produced through fermentation, then toxic compounds and expensive catalysts are eliminated, but the concentration of 1,4-diaminobutane in the fermentation solution is low
Solution Approach 1:
The patent extracts 1,4-diaminobutane from the fermentation solution through a multi-step process: first concentrating the fermentation solution to increase diamine concentration, then adjusting pH to precipitate salts, filtering to remove precipitates, and finally distilling to obtain high-purity 1,4-diaminobutane. This extraction process separates the desired product from the dilute fermentation medium.
Solution Approach 2:
The patent changes physical and chemical parameters of the fermentation solution to enable purification. Specifically, it adjusts pH from neutral to basic (pH 12 or higher) to precipitate diamine salts, then uses distillation to separate 1,4-diaminobutane based on volatility differences. These parameter changes transform the dilute fermentation solution into high-purity product.
2Device complexity
If conventional purification methods are used, then the process is simple, but high-purity 1,4-diaminobutane cannot be obtained
Solution Approach 1:
The patent divides the purification process into distinct sequential stages: concentration of fermentation solution, pH adjustment to precipitate salts, filtration to remove precipitates, and distillation to obtain pure product. Each stage addresses a specific purification need, and the combination of these segmented steps achieves high purity that single methods cannot provide.
3Manufacturing precision
If the fermentation solution is concentrated and pH is adjusted, then high-purity 1,4-diaminobutane is obtained, but the process requires multiple steps
Solution Approach 1:
The patent combines multiple purification functions into an integrated process flow where concentration, pH adjustment, precipitation, filtration, and distillation work together synergistically. The concentration step increases efficiency of subsequent steps, pH adjustment enables selective precipitation, and distillation provides final purification. This merged approach achieves high purity while maintaining practical processability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method achieves high-purity 1,4-diaminobutane with high yield by concentrating the fermentation solution, adjusting the pH, and recovering it through distillation, overcoming the limitations of existing methods by eliminating toxic compounds and expensive catalysts.
Implementation Method 1
concentrating a fermentation solution including at least one of 1,4-diaminobutane and a salt thereof and optionally bacterial cells
Implementation Method 2
adding a base to the concentrate of the fermentation solution to prepare an basic composition having a pH 12 or higher
Implementation Method 3
recovering 1,4-diaminobutane from the basic composition by distillation
Data Source
Figure 1~2
AI summary
A purification method of 1,4-diaminobutane, 1,4-diaminobutane purified using the purification method, and a polyamide prepared using the purified 1,4-diaminobutane are provided. The purification method of 1,4-diaminobutane includes: concentrating a fermentation solution including at least one of 1,4-diaminobutane and a salt thereof to obtain a concentrate; adding a base to the concentrate of the fermentation solution to prepare an basic composition having a pH 12 or higher; and recovering 1,4-diaminobutane from the basic composition.