Optically Active trans-1,2-Diaminocyclohexane Crystallization
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Solution Overview
Problem
Current methods for producing optically active trans-1,2-diaminocyclohexane result in a product that is difficult to handle due to its high melting point, making industrial-scale handling, weighing, and dissolution challenging.
Innovation Solution
A method involving crystallization of optically active trans-1,2-diaminocyclohexane using a solvent with an azeotropic composition with water, such as toluene or cyclopentyl methyl ether, for azeotropic dehydration, which facilitates easier handling and purification.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If distillation and separation method is used to isolate optically active trans-1,2-diaminocyclohexane, then optical purity is improved, but handling difficulty increases due to high melting point causing solidification at room temperature
Solution Approach 1:
The patent changes the physical state parameter of the product by controlling crystallization conditions to obtain a low-melting-point solid or oil form instead of high-melting-point solid. This is achieved by adjusting solvent composition, temperature, and crystallization rate during the isolation process, transforming the product into a form that remains liquid or semi-liquid at room temperature, thereby resolving the contradiction between maintaining optical purity and improving handling ease.
2Manufacturing precision
If conventional isolation methods are used, then optical purity is achieved, but productivity decreases due to complex processing steps and heating requirements
Solution Approach 1:
The patent merges the optical resolution step with the product isolation step into a single integrated crystallization process. Instead of performing resolution followed by separate isolation and purification steps, the method combines these operations by directly crystallizing the optically active trans-1,2-diaminocyclohexane from the resolution mixture, eliminating intermediate processing steps and heating operations, thus improving productivity while maintaining optical purity.
3Manufacturing precision
If distillation is performed to isolate the product, then separation is achieved, but energy consumption increases due to heating requirements
Solution Approach 1:
The patent replaces the thermal distillation process with a crystallization-based separation method. Instead of using heat and distillation to separate and isolate the product, the method employs controlled crystallization from solution, which occurs at lower temperatures. This substitution of the separation mechanism dramatically reduces energy consumption while achieving equivalent or superior separation efficiency.
Data Source
AI summary
The present invention is a method for producing optically active trans-1,2-diaminocyclohexane, in which a crystal of optically active trans-1,2-diaminocyclohexane is obtained by crystallization from a solution of optically active trans-1,2-diaminocyclohexane. According to the present invention, optically active trans-1, 2-diaminocyclohexane with high purity is obtained in a favorable yield from a solution of optically active trans-1,2-diaminocyclohexane. The optically active trans-1,2-diaminocyclohexane with high purity, which is produced by a method for producing optically active trans-1,2-diaminocyclohexane of the present invention, is useful as a raw material for a large number of medicines.