Double Wien Filter Tuning for High-Resolution Isotope Separation

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Solution Overview

Problem

Multicollector mass spectrometers face challenges in accurately determining isotope ratios due to isotopic interferences, requiring complex chemical cleaning steps and limiting analysis to high-quantity samples, especially when distinguishing between 87Sr and 87Rb, which necessitates a method to enhance mass resolution and reduce interference.

Innovation Solution

A method for tuning a static field mass filter with a combination of two Wien filters and lens adjustments to optimize ion transmission and focus, allowing for improved mass resolution and reduced interference, enabling accurate isotope ratio determination without altering the measured isotope ratios unpredictably.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a pre-filter comprising a combination of two Wien filters is used to block the intense Ar beam and reduce total ion load, then the resolving power and abundance sensitivity are improved, but the optimization of the pre-filter settings becomes non-intuitive and complex

Engineering Contradiction:
Improveresolving powerVSAvoidoptimization of pre-filter settings
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The patent implements an automated feedback-based optimization method that measures the transmission of specific ion species through the double Wien filter and adjusts the electric and magnetic field strengths accordingly. The system uses a control algorithm that iteratively optimizes the filter settings to achieve mass-independent transmission, eliminating the need for intuitive manual adjustment while maintaining high resolving power.

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The system performs self-optimization by automatically measuring its own transmission characteristics and adjusting its parameters. The control algorithm autonomously determines the optimal electric and magnetic field strengths without requiring external intervention or expert knowledge, allowing the instrument to self-tune for maximum performance.

Inventive Principle:
Principle #25Self-service

2Measurement precision

If complex chemical cleaning steps are used to remove isotopic interferences, then the accuracy of isotope ratio determination is improved, but the analysis time increases and the method is limited to samples available in relatively high quantities

Engineering Contradiction:
Improveaccuracy of isotope ratio determinationVSAvoidanalysis time
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent replaces complex chemical cleaning procedures with a physical separation method using a double Wien filter. This electromagnetic filtering system physically separates ions based on their mass-to-charge ratio, eliminating the need for time-consuming chemical processing steps while maintaining high accuracy in isotope ratio determination.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system changes the operating parameters of the mass spectrometer by introducing a static field mass filter with specific electric and magnetic field configurations. This parameter change enables direct physical separation of interfering ions from analyte ions, achieving high measurement precision without the need for chemical sample preparation.

Inventive Principle:
Principle #35Parameter changes

3Measurement precision

If the mass resolving power is increased to distinguish between 87Sr and 87Rb, then the ability to resolve isotopic interferences is improved, but the mass difference requires a mass resolving power of more than 200,000 which exceeds the upper limit of commercially available instruments

Engineering Contradiction:
Improvemass resolutionVSAvoidmass resolving power requirement
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the mass filtering function into two separate Wien filters arranged in series. Each filter provides partial mass separation, and together they achieve the required high resolving power. This segmentation allows the system to achieve mass resolution greater than 200,000 without requiring a single excessively complex filtering stage.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The double Wien filter system acts as an intermediary device between the ion source and the detector. It provides the necessary mass resolution by physically separating ions based on their mass-to-charge ratio before they reach the detector, enabling the distinction between 87Sr and 87Rb without requiring the entire mass spectrometer to operate at ultra-high resolving power.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enhances the mass spectrometer's ability to accurately measure isotope ratios by optimizing ion transmission and reducing interference, thereby improving the instrument's resolving power and abundance sensitivity, allowing for more precise analysis of isotope ratios without the need for extensive chemical cleaning.

Implementation Method 1

applying, in the first Wien filter, a first magnetic field and a first electric field having a first magnetic field strength and a first electric field strength, respectively, to deflect the beam into a respective subbeam for each ion species

Methodology Applied
Scientific EffectLorentz force: Lorentz Force

Implementation Method 2

applying, in the second Wien filter, a second magnetic field and a second electric field having the first magnetic field strength and the first electric field strength, respectively, to counter the deflection of the subbeams caused by the first Wien filter

Methodology Applied
Scientific EffectLorentz force: Lorentz Force

Implementation Method 3

adjusting a first lens (214) of the static field mass filter, positioned downstream of the first Wien filter and upstream of the second Wien filter, such that the trajectories of the subbeams downstream of the second Wien filter are substantially mass independent

Methodology Applied
Scientific EffectElectrostatic lens focusing: Electrostatic Lens

Data Source

PatentEP4339995A1Tuning a mass spectrometer comprising a double wien filter
Publication Date: 2024.03.20 THERMO FISHER SCI BREMEN
  • EP4339995A1 patent drawingFigure 1
  • EP4339995A1 patent drawingFigure 2A
  • EP4339995A1 patent drawingFigure 2B

AI summary

A method of tuning a static field mass filter of a mass spectrometer, the static field mass filter having a first Wien filter and a second Wien filter. The method comprises injecting a beam of ions into the static field mass filter, applying a magnetic and an electric field in the first and second Wien filters, adjusting a lens positioned downstream of the first Wien filter and upstream of the second Wien filter.