Drug Patch Roller Mechanism for Programmable Dosage Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current transdermal drug delivery systems lack precise control over timing, rate, and dosage, often leading to inefficiencies and potential side effects due to fixed delivery schedules and lack of synchronization with the body's natural rhythms or individual physiological conditions.
Innovation Solution
A system comprising a dosage control device with a roller and guide mechanism that adjusts the rate of patch engagement and disengagement, allowing for programmable and responsive delivery of drugs, including delayed engagement and disengagement, and varying the rate of drug administration based on pre-programmed schedules or real-time sensor data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional transdermal patch with fixed delivery schedule is used, then the device complexity is low, but the precision of drug delivery timing and dosage control is insufficient
Solution Approach 1:
A control device is introduced as an intermediary between the transdermal patch and the skin, which mediates the drug delivery process by controlling patch engagement and disengagement timing, thereby achieving precise dosage control without modifying the patch itself
Solution Approach 2:
The system transitions from static fixed-schedule delivery to dynamic controllable delivery, where the control device can adjust engagement and disengagement timing based on circadian rhythms and individual physiological conditions, enabling precise timing control
2Adaptability or versatility
If fixed delivery schedule is used, then the ease of operation is high, but the adaptability to circadian rhythms and individual conditions is poor
Solution Approach 1:
The system performs preliminary actions by pre-programming delivery schedules aligned with circadian rhythms and individual conditions before actual drug administration, allowing the control device to automatically adjust timing without requiring complex real-time decisions from the user
Solution Approach 2:
The system incorporates feedback mechanisms that monitor physiological conditions and circadian rhythms, using this information to dynamically adjust drug delivery timing and dosage, thereby achieving adaptability while maintaining ease of operation through automated control
3Reliability
If continuous drug delivery is used, then the therapeutic efficacy is maintained, but the side effects increase due to lack of synchronization with body rhythms
Solution Approach 1:
The system implements periodic action by scheduling drug delivery in pulses or intervals that synchronize with circadian rhythms and individual physiological conditions, rather than continuous delivery, thereby maintaining therapeutic efficacy while reducing side effects through timing optimization
Data Source
AI summary
Embodiments are disclosed of a method of controlling timing and/or dosage of a transdermal drug patch. For example, a control device operative to move the patch to one or more of a plurality of operational relationships with a skin of a patient, including being fully engaged with the skin, partially engaged with the skin, and disengaged with the skin. The device may include a roller that peels a patch on and off the skin. Optionally a convention patch is used. In some embodiments a patch and/or an adaptor has a mobile zone and an immobile zone. In some embodiments, an active surface of the patch fully contacts the skin in an engaged state. For example the patch may be attached to the device on a passive portion thereof.