Sample Analyzer With Dual Optical Measurement for Cell Counting
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Solution Overview
Problem
The accuracy of cell classification and counting in hematology tests depends on a particular measurement principle, leading to potential inaccuracies.
Innovation Solution
A sample analyzer that incorporates a first measurement unit using a single beam spot for optical interrogation and a second measurement unit using diffracted light patterns for optical interrogation, allowing for enhanced cell classification and counting through multiple light information analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If a single measurement principle is used for cell analysis, then the device complexity is reduced, but the measurement precision and reliability of cell classification and counting deteriorate
Solution Approach 1:
The patent combines multiple measurement units (first measurement unit with single beam spot and second measurement unit with diffracted light patterns) into a single sample analyzer system. This merging of different measurement principles allows the system to achieve higher measurement precision for cell classification and counting while maintaining integrated device complexity through unified control and data processing architecture.
2Reliability
If multiple measurement units with different principles are incorporated, then the measurement precision and reliability improve, but the device complexity increases
Solution Approach 1:
The sample analyzer is designed with multi-functionality, where the single sample analyzer can perform measurements using both the first measurement unit (single beam spot) and the second measurement unit (diffracted light patterns). This universal design allows the system to achieve improved reliability through multiple measurement principles while avoiding the complexity of having separate independent systems, as both measurement units share common components and control mechanisms.
3Measurement precision
If diffracted light patterns are used for optical interrogation, then the measurement precision for cell differentiation improves, but the device complexity increases due to additional optical components
Solution Approach 1:
The optical interrogation system is segmented into two distinct measurement units: the first measurement unit using a single beam spot and the second measurement unit using diffracted light patterns generated by a diffractive optical element. This segmentation allows the complex diffracted light pattern generation to be isolated in a dedicated unit, improving measurement precision for cell differentiation while managing device complexity through modular architecture where each unit can be independently optimized and controlled.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves the accuracy of cell classification and counting by leveraging different measurement principles, enabling better differentiation and counting of challenging cell types.
Implementation Method 1
the second illumination light includes a plurality of distributed lights generated by diffracting the light using the diffractive optical element (215)
Data Source
AI summary
A sample analyzer for analyzing cells in a sample collected from a subject according to one or more embodiment may include a first measurement unit configured to interrogate cells passing through at least one beam spot of a first illumination light to obtain first light information, a second measurement unit configured to interrogate cells passing through an irradiation area of a second illumination light to obtain second light information, wherein the second illumination light includes a plurality of distributed lights generated by diffracting a light using a diffractive optical element, and a controller configured to generate a cell analysis result based on one of (1) a first analysis result based on the first light information, (2) a second analysis result based on the second light information, and (3) the first analysis result and the second analysis result.