Electrode Substrate Replacement for Cell Resistance Measurement

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Solution Overview

Problem

Existing methods for measuring electrical resistance of biological cells or tissues face issues with unstable measurements due to electrode contamination and require complex cleaning processes.

Innovation Solution

An electrode substrate with a base section, extension parts, connection terminals, and engagement surfaces, along with a removal tool, facilitates easy attachment and detachment from a relay section, allowing for efficient and accurate electrical resistance measurement.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If electrodes are immersed in culture solution for prolonged measurement, then electrical resistance measurement can be maintained, but electrode contamination occurs and measurement accuracy deteriorates

Engineering Contradiction:
Improvemeasurement durationVSAvoidmeasurement accuracy
Core Design Contradiction:
Duration of action of stationary objectVSMeasurement precision

Solution Approach 1:

The electrode system is divided into a reusable relay section and a disposable electrode substrate. The electrode substrate can be easily detached and replaced when contaminated, allowing prolonged measurement capability without accuracy deterioration. The engagement surface with protruding or recessed shape enables quick identification and replacement of the electrode substrate.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The electrode substrate is designed as a disposable component that can be easily replaced. When the electrode substrate becomes contaminated during prolonged measurement, it is simply detached and replaced with a new one, maintaining measurement accuracy without requiring complex cleaning operations.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Measurement precision

If electrodes are cleaned when contaminated, then measurement accuracy can be maintained, but operational complexity and time consumption increase

Engineering Contradiction:
Improvemeasurement accuracyVSAvoidoperational simplicity
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

Instead of requiring complex cleaning operations, the electrode substrate is designed as a disposable component that is simply replaced when contaminated. This maintains measurement accuracy while greatly simplifying operations and reducing time consumption.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The electrode substrate is extracted as a separate, easily replaceable component from the measuring device. This allows the electrode to be removed and replaced without affecting the relay section or requiring complex cleaning procedures, thereby maintaining accuracy while simplifying operations.

Inventive Principle:
Principle #2Taking out (Extraction)

3Productivity

If electrode replacement is facilitated through simple design, then productivity increases, but engagement reliability may deteriorate

Engineering Contradiction:
Improveelectrode replacement efficiencyVSAvoidengagement reliability
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The engagement surface is designed with an asymmetric protruding or recessed shape that provides both easy identification and secure engagement. The asymmetric shape allows the electrode substrate to be easily inserted and identified by its unique shape, while simultaneously ensuring reliable engagement with the relay section through complementary geometric features.

Inventive Principle:
Principle #4Asymmetry

Data Source

PatentUS12442813B2Electrode substrate, measuring device, removal tool, and measuring method
Publication Date: 2025.10.14 SCREEN HOLDINGS CO LTD
  • US12442813B2 patent drawing
  • US12442813B2 patent drawing
  • US12442813B2 patent drawing

AI summary

A technique for measuring the electrical resistance of biological cells or tissues with high efficiency and with high accuracy is provided. An electrode substrate includes: a substrate having a base section, a first extension part extending from the base section, and a second extension part extending from the base section; a plurality of connection terminals provided on a first main surface of the substrate; a first working electrode and a second working electrode each connected to one of said connection terminals, the first and second working electrodes being wired on the first main surface of the substrate; and an engagement surface provided on the substrate and facing toward the connection terminals in a position closer to the first extension part than the connection terminals. The first working electrode is wired from the base section to the first extension part. The second working electrode is wired from the base section to the second extension part.